Prenatal morphine exposure alters susceptibility to bicuculline seizures in a sex- and age-specific manner
| Autor: | Jana Velíšková, Romana Šlamberová, Cheryl J Schindler, Ilona Vathy |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Brain development Convulsants Biology Bicuculline gamma-Aminobutyric acid Rats Sprague-Dawley Epilepsy Sex Factors Developmental Neuroscience Pregnancy Seizures Internal medicine medicine Animals gamma-Aminobutyric Acid Morphine Prenatal morphine Age Factors medicine.disease Age specific Rats Analgesics Opioid Endocrinology Prenatal Exposure Delayed Effects Female Disease Susceptibility Developmental Biology medicine.drug |
| Zdroj: | Developmental Brain Research. 121:119-122 |
| ISSN: | 0165-3806 |
| DOI: | 10.1016/s0165-3806(00)00031-6 |
| Popis: | Bicuculline was used to investigate seizure susceptibility in pre- and peripubertal male and female rats exposed prenatally to morphine. Morphine-exposed males showed increased seizure susceptibility at prepubertal and decreased susceptibility at peripubertal ages. There was no difference in seizure susceptibility in morphine-exposed females at either age. Therefore, the present data suggest that males are more vulnerable than females to morphine-induced insults during prenatal brain development. |
| Databáze: | OpenAIRE |
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