Novel virulence factor dupA of Helicobacter pylori as an important risk determinant for disease manifestation: An overview
| Autor: | Sangita Paul, Jawed Alam, Mou Ganguly, Bipul Chandra Karmakar, Avijit Sarkar, Asish K. Mukhopadhyay |
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| Rok vydání: | 2020 |
| Předmět: |
Virulence Factors
Population Disease Biology Virulence factor Helicobacter Infections Duodenal ulcer 03 medical and health sciences 0302 clinical medicine Bacterial Proteins Stomach Neoplasms Humans CagA dupA gene education Pathogen Genetics Antigens Bacterial education.field_of_study Plasticity region Helicobacter pylori Gastroenterology Minireviews General Medicine biology.organism_classification Pathogenicity island 030220 oncology & carcinogenesis Biomarker (medicine) 030211 gastroenterology & hepatology Gastric cancer |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v26.i32.4739 |
| Popis: | Helicobacter pylori (H. pylori) is a microaerophilic, Gram-negative, human gastric pathogen found usually in the mucous lining of stomach. It infects more than 50% of the world’s population and leads to gastroduodenal diseases. The outcome of disease depends on mainly three factors: Host genetics, environment and bacterial factors. Among these, bacterial virulence factors such as cagA, vacA are well known for their role in disease outcomes. However, based on the global epidemiological results, none of the bacterial virulence (gene) factors was found to be associated with particular diseases like duodenal ulcer (DU) in all populations. Hence, substantial importance has been provided for research in strain-specific genes outside the cag pathogenicity island, especially genes located within the plasticity regions. dupA found within the plasticity regions was first demonstrated in 2005 and was proposed for duodenal ulcer development and reduced risk of gastric cancer in certain geographical regions. Due to the discrepancies in report from different parts of the world in DU development related to H. pylori virulence factor, dupA became an interesting area of research in elucidating the role of this gene in the disease progression. In this review, we shed light on the detailed information available on the polymorphisms in dupA and their clinical relevance. We have critically appraised several pertinent studies on dupA and discussed their merits and shortcomings. This review also highlights dupA gene as an important biomarker for DU in certain populations. |
| Databáze: | OpenAIRE |
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