The association of patient age with postoperative morbidity and mortality following resection of intracranial tumors
| Autor: | Abdelhalim Hussein, Jiri Bartek, Yang Yang, Paolo Ferroli, Morgan Broggi, Marian Christoph Neidert, Luca Regli, Marike L. D. Broekman, Alexandra Sachkova, Claudine O. Nogarede, Julia Velz, Costanza M Zattra, Johannes Kerschbaumer, Petter Förander, Georg Neuloh, Veit Rohde, Alexander Fletcher-Sandersjöö, Anna M Zeitlberger, Mirjam Renovanz, Victor E. Staartjes, Kristin Sjåvik, Christian F. Freyschlag, Asgeir Store Jakola, Oliver Bozinov, Martin N. Stienen, Konstantin Brawanski, Cynthia M. C. Lemmens, Florian Ringel, Niklaus Krayenbühl, Flavio Vasella, Julius M Kernbach, Ole Solheim, Hans Christoph Bock, Darius Kalasauskas, Bawarjan Schatlo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
KPS Tumor resection Logistic regression Intracranial tumor Resection 03 medical and health sciences 0302 clinical medicine Age Patient age medicine In patient 10. No inequality RC346-429 Outcome Multivariable linear regression business.industry Functional status Odds ratio Surgery 030220 oncology & carcinogenesis Risk factor Neurology. Diseases of the nervous system business 030217 neurology & neurosurgery |
| Zdroj: | Brain and Spine, Vol 1, Iss, Pp 100304-(2021) |
| ISSN: | 2772-5294 |
| Popis: | Introduction The postoperative functional status of patients with intracranial tumors is influenced by patient-specific factors, including age. Research question This study aimed to elucidate the association between age and postoperative morbidity or mortality following the resection of brain tumors. Material and methods A multicenter database was retrospectively reviewed. Functional status was assessed before and 3–6 months after tumor resection by the Karnofsky Performance Scale (KPS). Uni- and multivariable linear regression were used to estimate the association of age with postoperative change in KPS. Logistic regression models for a ≥10-point decline in KPS or mortality were built for patients ≥75 years. Results The total sample of 4864 patients had a mean age of 56.4 ± 14.4 years. The mean change in pre-to postoperative KPS was −1.43. For each 1-year increase in patient age, the adjusted change in postoperative KPS was −0.11 (95% CI -0.14 - - 0.07). In multivariable analysis, patients ≥75 years had an odds ratio of 1.51 to experience postoperative functional decline (95%CI 1.21–1.88) and an odds ratio of 2.04 to die (95%CI 1.33–3.13), compared to younger patients. Discussion Patients with intracranial tumors treated surgically showed a minor decline in their postoperative functional status. Age was associated with this decline in function, but only to a small extent. Conclusion Patients ≥75 years were more likely to experience a clinically meaningful decline in function and about two times as likely to die within the first 6 months after surgery, compared to younger patients. |
| Databáze: | OpenAIRE |
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