Emotional Distress, Targeted Rejection, and Antibody Production After Influenza Vaccination in Adolescence

Autor: Kelsey L, Corallo, Sarah M, Lyle, Michael A, Carlock, Ted M, Ross, Katherine B, Ehrlich
Rok vydání: 2022
Předmět:
Zdroj: Psychosom Med
ISSN: 1534-7796
0033-3174
DOI: 10.1097/psy.0000000000001054
Popis: OBJECTIVE: The purpose of this study was to explore how both ongoing emotional distress and the experience of a targeted rejection over the past six months are associated with adolescents’ antibody response to influenza virus vaccination. We predicted that experiencing a targeted rejection would amplify the hypothesized negative association between emotional distress and antibody response following vaccination. METHODS: Adolescent participants (N = 148) completed two study visits (M days between visits = 27.4, SD = 1.8). At the first visit, they provided blood samples, were administered the seasonal (2018–2019) quadrivalent influenza vaccine (Fluzone™, Sanofi Pasteur), completed questionnaires, and participated in a semi-structured interview. At the second visit, they provided another blood sample. Hemagglutination-inhibition (HAI) assays were conducted to determine pre- and post-vaccination antibody titers. Targeted rejection experiences were coded from adolescents’ interviews. RESULTS: The Emotional Distress × Targeted Rejection interaction predicted antibody response to the two A strains and the composite of all vaccine strains (bs = −.451 to −.843, ps < .05), but not the two B strains. Results suggested that among adolescents who experienced a targeted rejection over the past six months, emotional distress was negatively associated with vaccine response (however, this finding did not reach statistical significance). Conversely, among adolescents who did not experience a targeted rejection, emotional distress was positively associated with vaccine response (b = 0.173, p = 0.032). CONCLUSION: The current study highlights the importance of evaluating both acute life events and ongoing distress as they relate to adaptive immune functioning in adolescence.
Databáze: OpenAIRE
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