Citrus Juice Modulates Antioxidant Enzymes and Lipid Profiles in Orchidectomized Rats
| Autor: | Julia Gonzalez, Erica Lopez, Bhimanagouda S. Patil, Farzad Deyhim, Michelle R. Garcia |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Citrus medicine.medical_specialty Antioxidant food.ingredient medicine.medical_treatment Medicine (miscellaneous) medicine.disease_cause Antioxidants Grapefruit juice Beverages Rats Sprague-Dawley Superoxide dismutase chemistry.chemical_compound food Internal medicine medicine Animals Triglycerides Orange juice Nutrition and Dietetics Triglyceride biology Superoxide Dismutase Cholesterol Catalase Lipids Rats Oxidative Stress Endocrinology Liver chemistry Fruit biology.protein Orchiectomy Oxidative stress Citrus paradisi Citrus sinensis |
| Zdroj: | Journal of Medicinal Food. 9:422-426 |
| ISSN: | 1557-7600 1096-620X |
| DOI: | 10.1089/jmf.2006.9.422 |
| Popis: | Oxidative stress and hypogonadism are two factors linked to the increased incidence of cardiovascular disease in males. Eating fruits and vegetables is known to reduce the incidences of oxidative stress. The objective of this research was to delineate whether drinking daily squeezed orange juice (OJ) or grapefruit juice (GJ) modulates oxidative stress and antioxidant enzymes while impacting cardiovascular risk factors in hypogonad male rats. In the present study, 36 1-year-old male rats were equally divided among the following four treatments: sham (control), orchidectomized (ORX), ORX + OJ, and ORX + GJ. After 60 days of drinking OJ or GJ, antioxidant capacity, cholesterol, and triglycerides in serum and superoxide dismutase (SOD), catalase (CAT), cholesterol, and triglycerides in liver were evaluated. Serum antioxidant capacity and SOD and CAT activities decreased (P < .05), while serum cholesterol and liver triglycerides increased (P < .05) in the ORX group compared with the sham group. In contrast to the ORX group, drinking OJ was ineffective while drinking GJ decreased (P < .05) cholesterol concentration in liver and in serum. Nevertheless, OJ and GJ decreased (P < .05) triglyceride concentration in liver and increased (P < .05) serum antioxidant capacity and SOD and CAT activities compared with the ORX group. In conclusion, drinking OJ or GJ prevented oxidative stress by enhancing total antioxidant capacity and elevating liver antioxidant enzymes while modulating cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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