SYT12 plays a critical role in oral cancer and may be a novel therapeutic target
| Autor: | Kazuyuki Koike, Toshikazu Takahara, Masashi Shiiba, Sho Wagai, Keitaro Eizuka, Noritoshi Oka, Dai Nakashima, Katsuhiro Uzawa, Atsushi Kasamatsu, Tomoaki Saito, Hideki Tanzawa |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell cycle checkpoint Regulator SYT12 03 medical and health sciences 0302 clinical medicine L-dopa Medicine Protein kinase A Gene knockdown business.industry Cancer medicine.disease Phenotype CAMK2N1 CAMK2 stomatognathic diseases 030104 developmental biology Oral squamous cell carcinoma Oncology Cell culture 030220 oncology & carcinogenesis Cancer research Immunohistochemistry business Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.32582 |
| Popis: | Synaptotagmin12 (SYT12) has been well characterized as the regulator of transmitter release in the nervous system, however the relevance and molecular mechanisms of SYT12 in oral squamous cell carcinoma (OSCC) are not understood. In the current study, we investigated the expression of SYT12 and its molecular biological functions in OSCC by quantitative reverse transcriptase polymerase chain reaction, immunoblot analysis, and immunohistochemistry. SYT12 were up-regulated significantly in OSCC-derived cell lines and primary OSCC tissue compared with the normal counterparts (P |
| Databáze: | OpenAIRE |
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