Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis
| Autor: | Qihong Zhao, Li Li, Kui Ye, Chao-Qun Yang, Zheng-Yu Wang, Shuang Hu, Qifei Liu, Yi Li |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology China Population Gastroenterology Inflammatory bowel disease Polymorphism Single Nucleotide Sensitivity and Specificity White People Asian People Crohn Disease Polymorphism (computer science) Predictive Value of Tests Risk Factors Internal medicine medicine Humans Genetic Predisposition to Disease Risk factor education STAT4 education.field_of_study Evidence-Based Medicine Hepatology business.industry STAT4 Transcription Factor medicine.disease Inflammatory Bowel Diseases Confidence interval Meta-analysis Colitis Ulcerative Gene polymorphism business Biomarkers |
| Zdroj: | Clinics and research in hepatology and gastroenterology. 39(5) |
| ISSN: | 2210-741X |
| Popis: | Summary Objective Association of Signal transducers and activators of transcription-4 (STAT4) gene polymorphism with susceptibility to inflammatory bowel disease have been investigated in a number of epidemiological studies, but the results are inclusive. The aim of this meta-analysis was to more precisely estimate the relationship. Methods The databases of Pubmed and CBM updated to October, 2014 were retrieved. Random- or fixed-effect model was used to estimate odd radio (OR) and corresponding 95% confidence interval (95%CI) on the basis of heterogeneity. Results Seven articles containing 2196 Crohn's disease (CD) cases, 1588 ulcerative colitis (UC) cases and 4126 controls were identified. We detected a significant association between STAT4 rs7574865 polymorphism and IBD susceptibility in overall population (GG vs. GT + TT, OR = 0.855, 95% CI = 0.760–0.962, P = 0.009), but not in Caucasian and Asian population, respectively. No association was detected between rs7574865 polymorphism and CD susceptibility in overall, Asian and Caucasian population, respectively. Interestingly, a significant association was detected between rs7574865 with UC susceptibility in overall population (G vs. T, OR = 0.881, 95% CI = 0.798–0.972, P = 0.012; GG vs. GT + TT, OR = 0.788, 95% CI = 0.679–0.914, P = 0.002; GG vs. TT, OR = 0.683, 95% CI = 0.498–0.937, P = 0.018) and Caucasians (GG vs. GT + TT, OR = 0.833, 95% CI = 0.701–0.990, P = 0.038; GG + GT vs. TT, OR = 0.667, 95% CI = 0.456–0.975, P = 0.037; GG vs. TT, OR = 0.636, 95% CI = 0.433–0.934, P = 0.021), respectively, and a possible association was found in Asian population (GG vs. GT + TT, OR = 0.709, 95% CI = 0.503–0.998, P = 0.049). Conclusions STAT4 rs7574865 gene is IBD risk factor, and this gene polymorphism is associated with UC susceptibility, especially in Caucasians. To confirm these findings, further studies with more sample size are required for a definitive conclusion. |
| Databáze: | OpenAIRE |
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