Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders

Autor: Ömer Faruk Demirel, Mahmut Cem Tarakcioglu, Ihsan Tezdig, Muhammed Tayyib Kadak, Ömer Faruk Özer, İhsan Çetin
Přispěvatelé: ÖZER, Ömer Faruk
Rok vydání: 2016
Předmět:
0301 basic medicine
Nogo Proteins
genetic structures
Autism Spectrum Disorder
Health
Toxicology and Mutagenesis
Clinical Biochemistry
Enzyme-Linked Immunosorbent Assay
Biochemistry
behavioral disciplines and activities
Elevated serum
03 medical and health sciences
0302 clinical medicine
mental disorders
Glial Fibrillary Acidic Protein
medicine
Humans
Child
Glial fibrillary acidic protein
biology
Cetin I.
Tezdig I.
TARAKCIOGLU M. C.
Kadak M. T.
Demirel O. F.
Ozer O. F.
-Serum levels of glial fibrillary acidic protein and Nogo-A in children with autism spectrum disorders-
BIOMARKERS
cilt.21
ss.614-618
2016
Case-control study
Serum concentration
medicine.disease
030104 developmental biology
nervous system
Autism spectrum disorder
Case-Control Studies
Immunology
biology.protein
Autism
030217 neurology & neurosurgery
Biomarkers
Zdroj: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 21(7)
ISSN: 1366-5804
Popis: Context: Improved biomarkers would facilitate the diagnosis and treatment of autism spectrum disorders (ASD).Objective: Our objective was to examine the levels of Nogo-A and glial fibrillary acidic protein (GFAP) in children with ASD.Materials and methods: Serum concentrations of GFAP and Nogo-A were determined by enzyme-linked immunosorbent assay.Results: In this preliminary study, we found that serum Nogo-A was not found significantly different between groups, while serum levels of GFAP were significantly lower in ASD than controls.Discussion and conclusions: It will be of great interest to determine other potential causes of elevated serum levels of GFAP, and whether this elevation has any phenotypic effect.
Databáze: OpenAIRE
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