Rethinking subthreshold effects in regulatory chemical risk assessments

Autor: Evgenios Agathokleous, Damià Barceló, Michael Aschner, Ricardo Antunes Azevedo, Prosun Bhattacharya, David Costantini, G. Christopher Cutler, Alessandra De Marco, Anca Oana Docea, José G. Dórea, Stephen O. Duke, Thomas Efferth, Despo Fatta-Kassinos, Vasileios Fotopoulos, Antonio Ginebreda, Raul Narciso C. Guedes, A. Wallace Hayes, Ivo Iavicoli, Olga-Ioanna Kalantzi, Takayoshi Koike, Demetrios Kouretas, Manish Kumar, José E. Manautou, Michael N. Moore, Elena Paoletti, Josep Peñuelas, Yolanda Picó, Russel J. Reiter, Ramin Rezaee, Jörg Rinklebe, Teresa Rocha-Santos, Pierre Sicard, Christian Sonne, Christopher Teaf, Aristidis Tsatsakis, Alexander I. Vardavas, Wenjie Wang, Eddy Y. Zeng, Edward J. Calabrese
Přispěvatelé: Agathokleous, E., Barcelo, D., Aschner, M., Azevedo, R. A., Bhattacharya, P., Costantini, D., Cutler, G. C., De Marco, A., Docea, A. O., Dorea, J. G., Duke, S. O., Efferth, T., Fatta-Kassinos, D., Fotopoulos, V., Ginebreda, A., Guedes, R. N. C., Hayes, A. W., Iavicoli, I., Kalantzi, O. -I., Koike, T., Kouretas, D., Kumar, M., Manautou, J. E., Moore, M. N., Paoletti, E., Penuelas, J., Pico, Y., Reiter, R. J., Rezaee, R., Rinklebe, J., Rocha-Santos, T., Sicard, P., Sonne, C., Teaf, C., Tsatsakis, A., Vardavas, A. I., Wang, W., Zeng, E. Y., Calabrese, E. J.
Rok vydání: 2022
Předmět:
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Agathokleous, E, Barceló, D, Aschner, M, Azevedo, R A, Bhattacharya, P, Costantini, D, Cutler, G C, De Marco, A, Docea, A O, Dórea, J G, Duke, S O, Efferth, T, Fatta-Kassinos, D, Fotopoulos, V, Ginebreda, A, Guedes, R N C, Hayes, A W, Iavicoli, I, Kalantzi, O I, Koike, T, Kouretas, D, Kumar, M, Manautou, J E, Moore, M N, Paoletti, E, Peñuelas, J, Picó, Y, Reiter, R J, Rezaee, R, Rinklebe, J, Rocha-Santos, T, Sicard, P, Sonne, C, Teaf, C, Tsatsakis, A, Vardavas, A I, Wang, W, Zeng, E Y & Calabrese, E J 2022, ' Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments ', Environmental Science and Technology, vol. 56, no. 16, pp. 11095-11099 . https://doi.org/10.1021/acs.est.2c02896
Digital.CSIC. Repositorio Institucional del CSIC
instname
DOI: 10.1021/acs.est.2c02896
Popis: A great number of dose–response studies indicate that hormesis is a common phenomenon, occurring in numerous organisms exposed to singular or combined environmental stressors, such as pharmaceuticals, heavy metals, micro/nanoplastics, organic flame retardants, pesticides, and rare earths. (1−6) While biological responses to low exposure levels are often beneficial, exposure to doses below the no-observed-adverse-effect-level (NOAEL; hereafter subthreshold doses) does not always translate to beneficial responses. (2,4) For example, subthreshold contaminant doses can enhance the virulence of phytopathogenic microbes and promote the resistance of crop pests with significant implications for crop production. (2,7,8) Subthreshold contaminant exposures can also stimulate infectious animal/human pathogens and promote their resistance to antibiotics and other drugs, threatening long-term sustainability. Importantly, the hormetic function of common pathways that regulate cancer progress indicate that current regulatory standards may not protect adequately against cancer risks. (9−11)
We are grateful to Dr. Patrick H. Brown, Distinguished Professor of Plant Science at the University of California, Davis, U.S.A., and Dr. Adrian Covaci, Professor of Environmental Toxicology and Chemistry at the University of Antwerp, Belgium, for comments and suggestions on an early draft of the paper. This study did not receive a specific grant from funding agencies in the public, commercial, or not-for-profit sectors. E.A. acknowledges support from the National Natural Science Foundation of China (No. 4210070867), The Startup Foundation for Introducing Talent of Nanjing University of Information Science & Technology (NUIST), Nanjing, China (No. 003080), and the Jiangsu Distinguished Professor program of the People’s Government of Jiangsu Province. E.J.C. acknowledges longtime support from the U.S. Air Force (AFOSR FA9550-13-1-0047) and ExxonMobil Foundation (S18200000000256). The sponsors were not involved in the study design; the collection, analysis or interpretation of the data; the preparation of the manuscript or the decision where to submit the manuscript for publication. All authors hold senior editorial positions in various scientific journals. The views presented herein are those of the authors and do not represent views of journals’ editorial board as a unit, journals’ editorial office, journals themselves or their publishers, authors’ institutions, or scientific societies where authors hold senior positions.
Databáze: OpenAIRE
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