Evaluation of a Summary Score for Dyslipidemia, Oxidative Stress and Inflammation (the Doi Score) in Women with Polycystic Ovary Syndrome and its Relationship with Obesity
| Autor: | Djuro Macut, Jelica Bjekic-Macut, Dusan Ilic, Ivana Božić-Antić, Zoran Andrić, Iva Perovic Blagojevic, Biljana Kastratovic-Kotlica, Svetlana Ignjatović, Jelena Vekic, Jelena Kotur-Stevuljevic |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
obesity DOI score 030209 endocrinology & metabolism Inflammation inflamacija medicine.disease_cause Gastroenterology lcsh:Biochemistry gojaznost 03 medical and health sciences chemistry.chemical_compound DOI skor 0302 clinical medicine Internal medicine medicine oxidative stress dislipidemija oksidativni stres lcsh:QD415-436 Polycystic ovary syndrome Original Paper 030219 obstetrics & reproductive medicine biology business.industry dyslipidemia Paraoxonase nutritional and metabolic diseases Malondialdehyde medicine.disease Polycystic ovary Obesity sindrom policističnih jajnika humanities 3. Good health chemistry inflammation biology.protein medicine.symptom business Weight gain Dyslipidemia Oxidative stress |
| Zdroj: | Journal of Medical Biochemistry Journal of Medical Biochemistry, Vol 37, Iss 4, Pp 476-485 (2018) Journal of Medical Biochemistry (2018) 37(4):476-485 |
| ISSN: | 1452-8258 |
| Popis: | Polycystic ovary syndrome (PCOS) is a cardiometabolic disorder whose features include dyslipidemia, increased oxidative stress (OS, oxy) and chronic inflammation. The aim of this study was to investigate the ability of a summary score for dyslipidemia, OS and inflammation (the DOI score) to discriminate PCOS patients from healthy individuals and to evaluate the effect of obesity on individual scores and the DOI score in patients.Lipid status parameters, OS status parameters (advanced oxidation protein products; total oxidative status; prooxidant-antioxidant balance; malondialdehyde; total protein sulphydryl groups and paraoxonase 1 activity) and CRP were measured in 114 patients and 50 controls using standardised assays. The DOI score was calculated as the sum of dyslipidemia, oxy and inflammation scores, determined as Z-score values for every subject in relation to the controls.PCOS patients had significantly higher oxy-score compared to controls (P0.001). In addition, the DOI score was significantly higher in PCOS patients (P0.001) as the dyslipidemia (P0.05) and inflammatory scores (P0.001) were greater. According to ROC analysis, the oxy-score showed better diagnostic accuracy in discriminating PCOS patients compared to the DOI score (AUC0.9, P0.01). Furthermore, obesity affected the risk scores in patients, especially the DOI score (significantly higher DOI scores in such patients, P0.001).PCOS patients had greater dyslipidemia, chronic inflammation and OS compared to controls and could be segregated using all four scores. Our data suggest that weight gain could be the common factor responsible for induction and propagation of dyslipidemia, OS and inflammation in PCOS patients.Sindrom policističnih jajnika (PCOS) je kardiometabolički poremećaj čije su karakteristike dislipidemija, povišen oksidativni stres (OS) i hronična inflamacija. Cilj ove studije je bio da se ispita sposobnost zbirnog skora dislipidemije, OS i inflamacije (DOI skor) da razlikuje pacijentkinje sa PCOS u poređenju sa zdravim osobama i da se proceni uticaj gojaznosti na pojedinačne skorove i DOI skor kod pacijentkinja.Parametri lipidnog statusa, parametri oksidativnog stresa (uznapredovali produkti oksidacije proteina; ukupni oksidativni status; prooksidativno-antioksidativni balans; malondialdehid; ukupne sulfhidrilne grupe i aktivnost paraoksonaze 1) i CRP su određivani kod 114 pacijentkinja i 50 kontrolnih ispitanica primenom standardizovanih testova. DOI skor je izračunat kao zbir skora dislipidemije, oksidativnog skora i skora inflamacije, određen kao vrednosti Z-skora za svaki subjekt u odnosu na kontrole.PCOS pacijentkinje su imale značajno više vrednosti oksidativnog skora u poređenju sa kontrolnom grupom (P0,001). Zatim, DOI skor je bio značajno viši kod pacijentkinja sa PCOS (P0,001) kao i skorovi dislipidemije (P0,05) i inflamacije (P0,001). Prema rezultatima ROC analize, oksidativni skor je pokazao bolju dijagnostičku tačnost u razlikovanju PCOS pacijentkinja u odnosu na zdrave osobe u poređenju sa DOI skorom (AUC0,9, P0,01). Osim toga, gojaznost je imala uticaj na vrednosti skorova rizika, posebno na DOI skor (vrednosti DOI skora su bile značajno više kod tih pacijentkinja, P0,001).Pacijentkinje sa PCOS su imale izraženiju dislipidemiju, hroničnu inflamaciju i oksidativni stres u poređenju sa kontrolnim ispitanicama i mogu se od njih razlikovati primenom sva četiri skora. Naši rezultati ukazuju da povećanje telesne težine može biti zajednički faktor odgovoran za nastanak i napredovanje dislipidemije, OS i inflamacije kod pacijentkinja sa PCOS. |
| Databáze: | OpenAIRE |
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