Efficacy of desloratadine in intermittent allergic rhinitis: a GA 2 LEN study
| Autor: | Bousquet, J, Bachert, C, Canonica, G W, Mullol, J, Van Cauwenberge, P, Bindslev Jensen, C, Fokkens, W J, Ring, J, Keith, P, Lorber, R, Zuberbier, T, study group, ACCEPT-1 |
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| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, Ear, Nose and Throat |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Histamine H1 Antagonists Non-Sedating Allergy medicine.medical_specialty Rhinitis Allergic Perennial Time Factors Visual analogue scale Immunology Placebo Severity of Illness Index law.invention Young Adult Double-Blind Method Randomized controlled trial law Internal medicine Clinical endpoint medicine Humans Immunology and Allergy Adverse effect Asthma Desloratadine business.industry Rhinitis Allergic Seasonal Loratadine Middle Aged medicine.disease Treatment Outcome Anesthesia Quality of Life Female business medicine.drug |
| Zdroj: | Bousquet, J, Bachert, C, Canonica, G W, Mullol, J, Van Cauwenberge, P, Bindslev Jensen, C, Fokkens, W J, Ring, J, Keith, P, Lorber, R, Zuberbier, T & study group, ACCEPT 2009, ' Efficacy of desloratadine in intermittent allergic rhinitis: a GA(2)LEN study ', Allergy. European Journal of Allergy and Clinical Immunology, vol. 64, no. 10, pp. 1516-23 . https://doi.org/10.1111/j.1398-9995.2009.02115.x Allergy, 64(10), 1516-1523. Wiley-Blackwell |
| ISSN: | 1398-9995 0105-4538 |
| Popis: | Udgivelsesdato: 2009-Oct BACKGROUND: The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines proposed a classification for allergic rhinitis based on the duration of symptoms (intermittent, persistent) rather than on the time of allergen exposure (seasonal, perennial). There is no placebo-controlled, randomized clinical trial on intermittent allergic rhinitis (IAR) to date. Desloratadine (DL) is recommended for the first-line treatment of seasonal and perennial allergic rhinitis. OBJECTIVES: To assess the efficacy and safety of DL in subjects with IAR based on the ARIA classification. METHODS: Patients over 12 years of age with IAR were assessed over 15 days of treatment with DL 5 mg once daily (n = 276) or placebo (n = 271). The primary endpoint was the AM/PM reflective total 5 symptom score (T5SS). Secondary endpoints included AM/PM instantaneous T5SS and individual symptoms, therapeutic response, symptom severity by visual analogue scale, and quality-of-life. RESULTS: The mean reduction of AM/PM reflective T5SS was significantly greater with DL than with placebo over 15 days (-3.01 vs-2.13, P < 0.001) and on each individual day (P < 0.05). Mean AM instantaneous T5SS was reduced significantly with DL compared to placebo as early as day 2 (-1.84 vs-0.89; P < 0.001). The therapeutic response and improvement in quality-of-life were significantly greater with DL than with placebo (P < 0.001 for each). The frequency of treatment-related adverse events was low and similar between DL (7.2%) and placebo (7.0%). CONCLUSIONS: This is the first large trial to show that treatment can be effective in IAR. Desloratadine was effective and safe. |
| Databáze: | OpenAIRE |
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