RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer
| Autor: | Cheng Wang, Zhibin Hu, Juncheng Dai, Fangzhi Du, Tao Jiang, Na Qin, Fei Chen, Fengliang Wang, Hongbing Shen, Jiangbo Du, Yuancheng Li, Cheng Lu, Yue Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
010401 analytical chemistry
RNA-Seq 02 engineering and technology General Medicine Biology 021001 nanoscience & nanotechnology medicine.disease_cause medicine.disease 01 natural sciences General Biochemistry Genetics and Molecular Biology 0104 chemical sciences Breast cancer medicine Cancer research Original Article 0210 nano-technology Carcinogenesis Mammary gland morphogenesis Gene Triple-negative breast cancer Survival analysis Hormone |
| Zdroj: | J Biomed Res |
| ISSN: | 1674-8301 |
| DOI: | 10.7555/jbr.34.20190111 |
| Popis: | Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC. Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas (TCGA). Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes. Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis. In this report, we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways, suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types. Further survival analysis revealed that nine genes ( FSIP1, ADCY5, FSD1, HMSD, CMTM5, AFF3, CYP2A7, ATP1A2, and C11orf86) were significantly associated with the prognosis of TNBC patients, while three of them ( ADCY5, CYP2A7, and ATP1A2) were involved in the hormone-related pathways. These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC. |
| Databáze: | OpenAIRE |
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