Long-term adherence to inhaled corticosteroids and asthma control in adult-onset asthma
| Autor: | Iida Vähätalo, Hannu Kankaanranta, Onni Niemelä, Lauri Lehtimäki, Pinja Ilmarinen, Leena E. Tuomisto |
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| Přispěvatelé: | Tampere University, Clinical Medicine, Seinäjoen keskussairaala VA, Department of Respiratory medicine, Dermatology and Allergology, BioMediTech |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry lcsh:R lcsh:Medicine Inhaled corticosteroids Original Articles Guideline Disease 3121 Internal medicine medicine.disease Disease control Asthma respiratory tract diseases Poor adherence immune system diseases Adult onset asthma Internal medicine Asthma control medicine In patient business |
| Zdroj: | ERJ Open Research article-version (VoR) Version of Record ERJ Open Research, Vol 7, Iss 1 (2021) |
| ISSN: | 2312-0541 |
| Popis: | Background In short-term studies, poor adherence to inhaled corticosteroids (ICS) has been associated with worse asthma control, but the association of long-term adherence and disease control remains unclear. Objective To assess the relationship between 12-year adherence to ICS and asthma control in patients with adult-onset asthma. Methods As part of the Seinäjoki Adult Asthma Study, 181 patients with clinically confirmed new-onset adult asthma and regular ICS medication were followed-up for 12 years. Adherence (%) to ICS was assessed individually ((µg dispensed/µg prescribed)×100) during the follow-up. Asthma control was evaluated after 12 years of treatment according to the Global Initiative for Asthma 2010 guideline. Results Asthma was controlled in 31% and not controlled (partly controlled or uncontrolled) in 69% of the patients. Patients with not-controlled asthma were more often male, older, nonatopic and used higher doses of ICS than those with controlled disease. The mean±sd 12-year adherence to ICS was 63±38% in patients with controlled asthma and 76±40% in patients with not-controlled disease (p=0.042). Among patients with not-controlled asthma, those with lower 12-year adherence ( Patients with not-controlled asthma and poor adherence show increased FEV1 decline. Special emphasis should be placed on ICS adherence in subjects who do not have controlled asthma, as they seem to be at higher risk of developing fixed airway obstruction. https://bit.ly/2LOXL4f |
| Databáze: | OpenAIRE |
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