Immunohistochemical study of pro-apoptotic factors Bax, Fas and CPP32 in urinary bladder cancer: prognostic implications
| Autor: | Aris Giannopoulos, Anastasios Zervas, Lydia Nakopoulou, Panagiotis Davaris, Constandinos Stravodimos, Andreas C. Lazaris, Ioanna Giannopoulou |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Nephrology
medicine.medical_specialty Pathology Clinical chemistry Urology Apoptosis Caspase 3 Proto-Oncogene Proteins Internal medicine In Situ Nick-End Labeling medicine Humans fas Receptor bcl-2-Associated X Protein TUNEL assay Urinary bladder business.industry Prognosis Fas receptor Immunohistochemistry Survival Analysis medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Urinary Bladder Neoplasms Caspases Multivariate Analysis business |
| Zdroj: | Urological Research. 30:342-345 |
| ISSN: | 1434-0879 0300-5623 |
| DOI: | 10.1007/s00240-002-0274-1 |
| Popis: | Apoptosis is a process which can retard the progress of malignant tumours. In the present study we investigated the immunohistochemical expression of three pro-apoptotic proteins (Bax, Fas receptor and caspase 3 - CPP32) as well as the apoptotic index (TUNEL Index) in 53 urothelial carcinomas of the urinary bladder. We examined all possible relationships between these factors and clinicopathological variables, as well as the patients' disease free survival. All three markers, and in particular the Fas receptor, were detectable in a remarkable proportion of specimens, however, none of the markers examined was associated with any clinicopathological parameter. In multivariate statistical analysis, Bax emerged as an independent predictor of a favourable prognosis. It is noteworthy that none of the pro-apoptotic markers examined was directly linked with the apoptotic rate of the malignant cells. |
| Databáze: | OpenAIRE |
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