β-Cells Different Vulnerability to the Parkinsonian Neurotoxins Rotenone, 1-Methyl-4-phenylpyridinium (MPP+) and 6-Hydroxydopamine (6-OHDA)
| Autor: | Vincenzo De Tata, Francesca Vaglini, Roberto Maggio, Giovanni Corsini, Michela Novelli, Gianluca Citi, Matilde Masini, Marco Scarselli, Shivakumar Kolachalam, M. Carli, Eleonora Risaliti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Parkinson's disease 1-Methyl-4-phenylpyridinium Population Pharmaceutical Science Pharmacology rotenone 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacy and materia medica Dopaminergic Cell Drug Discovery medicine education Metformin Neurotoxins Parkinson’s disease Pesticides Rotenone Type 2 diabetes α-tocopherol Hydroxydopamine education.field_of_study Dopaminergic pesticides medicine.disease RS1-441 030104 developmental biology chemistry Toxicity Molecular Medicine neurotoxins Medicine type 2 diabetes metformin 030217 neurology & neurosurgery |
| Zdroj: | Pharmaceuticals, Vol 14, Iss 767, p 767 (2021) Pharmaceuticals Volume 14 Issue 8 |
| ISSN: | 1424-8247 |
| Popis: | Neurotoxins such as rotenone, 1-methyl-4-phenylpyridinium (MPP+) and 6-hydroxydopamine (6-OHDA) are well known for their high toxicity on dopaminergic neurons and are associated with Parkinson’s disease (PD) in murine models and humans. In addition, PD patients often have glucose intolerance and may develop type 2 diabetes (T2D), whereas T2D patients have higher risk of PD compared to general population. Based on these premises, we evaluated the toxicity of these three toxins on pancreatic β-cell lines (INS-1 832/13 and MIN6) and we showed that rotenone is the most potent for reducing β-cells viability and altering mitochondrial structure and bioenergetics in the low nanomolar range, similar to that found in dopaminergic cell lines. MPP+ and 6-OHDA show similar effects but at higher concentration. Importantly, rotenone-induced toxicity was counteracted by α-tocopherol and partially by metformin, which are endowed with strong antioxidative and cytoprotective properties. These data show similarities between dopaminergic neurons and β-cells in terms of vulnerability to toxins and pharmacological agents capable to protect both cell types. |
| Databáze: | OpenAIRE |
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