Effects of growth and aging on the reference values of pulmonary nitric oxide dynamics in healthy subjects
| Autor: | Högman M, Thornadtsson A, Liv P, Hua-Huy T, At, Dinh-Xuan, Tufvesson E, Holger Dressel, Janson C, Koskela K, Oksa P, Sauni R, Uitti J, Moilanen E, Lehtimäki L |
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| Přispěvatelé: | University of Zurich, Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Medicin och hälsovetenskap Aging Adolescent Respiratory System 610 Medicine & health Nitric Oxide Medical and Health Sciences Young Adult nitric oxide Reference Values Humans Child Lung Aged breath test Sisätaudit - Internal medicine health 10060 Epidemiology Biostatistics and Prevention Institute (EBPI) Middle Aged respiratory system Healthy Volunteers Breath Tests Exhalation 2740 Pulmonary and Respiratory Medicine pulmonary gas exchange Regression Analysis Female mathematical model |
| Zdroj: | Europe PubMed Central |
| Popis: | The lung just like all other organs is affected by age. The lung matures by the age of 20 and age-related changes start around middle age, at 40-50 years. Exhaled nitric oxide (FENO) has been shown to be age, height and gender dependent. We hypothesize that the nitric oxide (NO) parameters alveolar NO (CANO), airway flux (J(aw)NO), airway diffusing capacity (DawNO) and airway wall content (CawNO) will also demonstrate this dependence. Data from healthy subjects were gathered by the current authors from their earlier publications in which healthy individuals were included as control subjects. Healthy subjects (n=433) ranged in age from 7 to 78 years. Age-stratified reference values of the NO parameters were significantly different. Gender differences were only observed in the 20-49 age group. The results from the multiple regression models in subjects older than 20 years revealed that age, height and gender interaction together explained 6% of variation in F(E)NOat 50 ml s(-1) (FENO50), 4% in JawNO, 16% inC(aw)NO, 8% in DawNO and 12% in CANO. In conclusion, in this study we have generated reference values for NO parameters from an extended NO analysis of healthy subjects. This is important in order to be able to use these parameters in clinical practice. |
| Databáze: | OpenAIRE |
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