One-year Cognitive Outcomes Associated with Carotid Artery Stent Placement
| Autor: | Robert Short, Robert B. Burr, Rodney D. Raabe |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Washington medicine.medical_specialty Adolescent medicine.medical_treatment Comorbidity Carotid endarterectomy Revascularization Asymptomatic law.invention Young Adult Age Distribution Randomized controlled trial law Prevalence medicine Humans Carotid Stenosis Radiology Nuclear Medicine and imaging Longitudinal Studies Sex Distribution Aged Aged 80 and over business.industry Stent Middle Aged medicine.disease Surgery Stenosis Treatment Outcome Female Stents medicine.symptom Cognition Disorders Cardiology and Cardiovascular Medicine business Neurocognitive |
| Zdroj: | Journal of Vascular and Interventional Radiology. 21:983-988 |
| ISSN: | 1051-0443 |
| DOI: | 10.1016/j.jvir.2010.03.011 |
| Popis: | To assess relatively long-term (ie, 1 year) neurocognitive outcomes of patients undergoing carotid artery stent (CAS) placement with cerebral protection.Sixty-two patients (19 symptomatic; mean age, 73 years) with significant carotid stenosis (or = 70% for symptomatic patients,or = 80% for asymptomatic patients) underwent CAS placement with embolic protection. Cognitive function was assessed prospectively with use of a battery of standardized tests administered at baseline (1-5 days before CAS endovascular therapy) and at 3, 6, and 12 months after CAS placement. Diffusion-weighted imaging (DWI) was performed before the procedure and within 24 hours after CAS placement.Results of statistical modeling across occasions of measurement indicated significant main effects of occasion for the Dementia Rating Scale (DRS)-2 concept formation (P.001), memory (P = .029), and total scores (P = .001); the DRS-2 total age- and education-corrected Mayo Older Americans Normative Studies score (P.001); and the North American Adult Reading Test IQ score (P = .003). The vast majority of patients showed improvement or no change relative to baseline DRS-2 total scores at all time points. No significant relationship between DWI outcomes and cognition scores over time was found. Age influenced improvement on cognitive tests, whereas baseline symptom status did not.Revascularization with a carotid stent and neuroprotection, at a minimum, left cognitive function unchanged in patients receiving a CAS, and in many instances improved it. The preliminary findings of this prospective pilot study should be confirmed with a larger, controlled trial. |
| Databáze: | OpenAIRE |
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