The microbiome and resistome of chimpanzees, gorillas, and humans across host lifestyle and geography
| Autor: | Tayte Campbell, Crickette M. Sanz, Vishal H. Patel, Xiaoqing Sun, Gautam Dantas, David Morgan |
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| Rok vydání: | 2020 |
| Předmět: |
Pan troglodytes
Range (biology) Biology Microbiology Article 03 medical and health sciences Abundance (ecology) Animals Humans Microbiome Life Style Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences Gorilla gorilla Bacteria Geography Resistance (ecology) 030306 microbiology Host (biology) Microbiota Drug Resistance Microbial Anti-Bacterial Agents Gastrointestinal Microbiome Resistome Evolutionary biology Metagenomics Species richness |
| Zdroj: | ISME J |
| ISSN: | 1751-7370 1751-7362 |
| Popis: | The gut microbiome can vary across differences in host lifestyle, geography, and host species. By comparing closely related host species across varying lifestyles and geography, we can evaluate the relative contributions of these factors in structuring the composition and functions of the microbiome. Here we show that the gut microbial taxa, microbial gene family composition, and resistomes of great apes and humans are more related by host lifestyle than geography. We show that captive chimpanzees and gorillas are enriched for microbial genera commonly found in non-Westernized humans. Captive ape microbiomes also had up to ~34-fold higher abundance and up to ~5-fold higher richness of all antibiotic resistance genes compared with wild apes. Through functional metagenomics, we identified a number of novel antibiotic resistance genes, including a gene conferring resistance to colistin, an antibiotic of last resort. Finally, by comparing our study cohorts to human and ape gut microbiomes from a diverse range of environments and lifestyles, we find that the influence of host lifestyle is robust to various geographic locations. |
| Databáze: | OpenAIRE |
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