Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q
| Autor: | Ikuroh Ohsawa, Takuji Shirasawa, Mayumi Takahashi, Kazuhide Takahashi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Ubiquinone Vesicular glutamate transporter 1 Normal aging Motor Activity Mitochondrion Biochemistry Mice 03 medical and health sciences chemistry.chemical_compound Oxygen Consumption 0302 clinical medicine Endocrinology Internal medicine Genetics medicine Animals Phosphorylation Molecular Biology Alpha-synuclein biology business.industry Motor Cortex Parkinson Disease Motor impairment Cell Biology Mitochondria Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure chemistry Coenzyme Q – cytochrome c reductase Vesicular Glutamate Transport Protein 1 alpha-Synuclein biology.protein business 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Experimental Gerontology. 81:65-75 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2016.04.023 |
| Popis: | Brain mitochondrial function declines with age; however, the accompanying behavioral and histological alterations that are characteristic of Parkinson's disease (PD) are poorly understood. We found that the mitochondrial oxygen consumption rate (OCR) and coenzyme Q (CoQ) content were reduced in aged (15-month-old) male mice compared to those in young (6-month-old) male mice. Concomitantly, motor functions, including the rate of movement and exploratory and voluntary motor activities, were significantly reduced in the aged mice compared to the young mice. In the motor cortex of the aged mouse brain, the accumulation of α-synuclein (α-syn) phosphorylated at serine129 (Ser129) significantly increased, and the level of vesicular glutamate transporter 1 (VGluT1) decreased compared with that in the young mouse brain. The administration of exogenous water-soluble CoQ10 to aged mice via drinking water restored the mitochondrial OCR, motor function, and phosphorylated α-syn and VGluT1 levels in the motor cortex. These results suggest that early-onset motor impairment and the increased accumulation of Ser129-phosphorylated α-syn in the motor cortex are ameliorated by the exogenous administration of CoQ10. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect