Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases

Autor: Reem Al-Daccak, Jean-David Bouaziz, Nabila Jabrane-Ferrat, Enzo Manchon, Nell Hirt
Přispěvatelé: Benson-Rumiz, Alicia, Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial - - MEDIMACS2017 - ANR-17-HDIM-0005 - JPI HDHL - VALID, Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-17-HDIM-0005,MEDIMACS,Impact of MEditerranean Diet, Inflammation and Microbiome on plaque vulnerability and microvascular dysfunction after an Acute Coronary Syndrome. A randomized, controlled, mechanistic clinical trial(2017)
Rok vydání: 2021
Předmět:
skin
chronic inflammation
Cell type
Cell
regenerative medicine
Dermatitis
wound healing
Context (language use)
Review
exosomes
Regenerative medicine
Theranostic Nanomedicine
Catalysis
Immunomodulation
lcsh:Chemistry
Inorganic Chemistry
Paracrine signalling
stem cells
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
medicine
Humans
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Spectroscopy
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
business.industry
Regeneration (biology)
Organic Chemistry
Biological Transport
General Medicine
Microvesicles
Computer Science Applications
Cell biology
medicine.anatomical_structure
lcsh:Biology (General)
lcsh:QD1-999
Chronic Disease
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Stem cell
extracellular vesicles
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2021, 22 (6), pp.3130. ⟨10.3390/ijms22063130⟩
International Journal of Molecular Sciences, Vol 22, Iss 3130, p 3130 (2021)
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms22063130
Popis: International audience; Endosome-derived small extracellular vesicles (EVs), often referred to as exosomes, are produced by almost all, if not all, cell types, and are critical for intercellular communication. They are composed of a lipid bilayer associated with membrane proteins and contain a payload of lipids, proteins and regulatory RNAs that depends on the parental cell physiological condition. By transferring their “cargo”, exosomes can modulate the phenotype of neighboring and distant cells. Stem cells (SC) were widely studied for therapeutic applications regarding their regenerative/reparative potential as well as their immunomodulatory properties. Whether from autologous or allogeneic source, SC beneficial effects in terms of repair and regeneration are largely attributed to their paracrine signaling notably through secreted EVs. Subsequently, SC-derived EVs have been investigated for the treatment of various diseases, including inflammatory skin disorders, and are today fast-track cell-free tools for regenerative/reparative strategies. Yet, their clinical application is still facing considerable challenges, including production and isolation procedures, and optimal cell source. Within the emerging concept of “allogeneic-driven benefit” for SC-based therapies, the use of EVs from allogeneic sources becomes the pragmatic choice although a universal allogeneic cell source is still needed. As a unique temporary organ that ensures the mutual coexistence of two allogeneic organisms, mother and fetus, the human placenta offers a persuasive allogeneic stem cell source for development of therapeutic EVs. Advancing cell-free therapeutics nurtures great hope and provides new perspectives for the development of safe and effective treatment in regenerative/reparative medicine and beyond. We will outline the current state of the art in regard of EVs, summarize their therapeutic potential in the context of skin inflammatory disorders, and discuss their translational advantages and hurdles.
Databáze: OpenAIRE
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