Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseases
| Autor: | Yun, Chen, Yunhui, Gu, Xing, Xiong, Yangyang, Zheng, Xiao, Liu, Weiqi, Wang, Guoliang, Meng |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Pharmacology Tumor Necrosis Factor-alpha Infant Newborn Apoptosis General Medicine TNF Receptor-Associated Factor 2 Communicable Diseases TNF Receptor-Associated Death Domain Protein Cardiovascular Diseases Death Domain Receptors Tumor Necrosis Factor Type I Humans Premature Birth Female Adaptor Proteins Signal Transducing |
| Zdroj: | Biomedicine & Pharmacotherapy. 153:113467 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2022.113467 |
| Popis: | Cells communication in response to extracellular or biophysical stimulus relies on elaborated systems of signal transduction. In the course of most signal pathway, the cascades involve signal protein complexes, which are often assembled by adaptor proteins. Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) is an adaptor molecule involved in various signal pathways and mediating multiple biological activities, including cell survival, cell proliferation, cell differentiation, apoptosis, necroptosis and inflammation. TRADD contains an N terminal tumor necrosis factor receptor-associated factor 2 (TRAF2) binding domain and a C terminal death domain (DD) for interacting with multiple DD-containing proteins. Following activation of specific receptors, such as tumor necrosis factor receptor 1 (TNFR1), death receptor 3 (DR3), tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAILR1, DR4), TRAILR1 (DR5), DR6 and p75 neurotrophin receptor (p75 |
| Databáze: | OpenAIRE |
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