Serum Cathepsin H as a Potential Prognostic Marker in Patients with Colorectal Cancer

Autor:	Ib Jarle Christensen, Hans Jørgen Nielsen, N. Brünner, A Schweiger, Janko Kos, Steen Sørensen
Rok vydání:	2004
Předmět:	Adult Male 0301 basic medicine Cathepsin H medicine.medical_specialty Pathology Cancer Research Time Factors Colorectal cancer Cathepsin L Clinical Biochemistry Enzyme-Linked Immunosorbent Assay Gastroenterology Cathepsin B Pathology and Forensic Medicine 03 medical and health sciences Sex Factors Carcinoembryonic antigen 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Humans Neoplasm Metastasis Stage (cooking) Survival analysis Aged Aged 80 and over biology business.industry Hazard ratio Age Factors Middle Aged Prognosis medicine.disease Cathepsins Carcinoembryonic Antigen Cysteine Endopeptidases 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Multivariate Analysis biology.protein Female Colorectal Neoplasms business
Zdroj:	The International Journal of Biological Markers. 19:289-294
ISSN:	1724-6008
DOI:	10.1177/172460080401900406
Popis:	Cathepsin H is a lysosomal cysteine protease that may participate in tumor progression. In order to evaluate its potential as a prognostic marker, its protein levels were measured by ELISA in preoperative sera from 324 patients with colorectal cancer. The level of cathepsin H was significantly increased in patient sera, the median level was 8.4 ng/mL versus 2.1 ng/mL in 90 healthy blood donors (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12806bb3dbb44e29bf265514d258ffe https://doi.org/10.1177/172460080401900406 Zobrazit plný text záznamu