Scleroderma Renal Crisis Debute with Thrombotic Microangiopathy: A Successful Case Treated with Eculizumab
| Autor: | Carolina Larrarte, Maite Hurtado Uriarte, Laura Bravo Rey |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
Thrombotic microangiopathy business.industry medicine.medical_treatment Scleroderma Renal Crisis 030232 urology & nephrology Thrombotic thrombocytopenic purpura Case Report Microangiopathic hemolytic anemia Eculizumab medicine.disease Systemic scleroderma lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 03 medical and health sciences 0302 clinical medicine Nephrology Immunology medicine Renal replacement therapy Immune disorder business medicine.drug |
| Zdroj: | Case Reports in Nephrology, Vol 2018 (2018) Case Reports in Nephrology |
| ISSN: | 2090-6641 |
| Popis: | We had the challenged to treat a 40-year-old female with Systemic Scleroderma who was showing unspecific symptoms. During her time at the hospital she rapidly develops renal dysfunction, associated with hypertension. She required renal replacement therapy initiation and we observed a decline in hemoglobin and platelets numbers. We confirm a microangiopathic hemolytic anemia and rule out other immune diseases or thrombotic thrombocytopenic purpura. Systemic Sclerosis is a chronic immune disorder of unknown origin that it is not completely understood. It is believed that environmental factors may contribute and also altered genes may be implicated in the immune system’s function. Microangiopathic hemolytic anemia occurs in 43% of patients who develop scleroderma renal crisis and an activation of the complement system through the classical pathway may be involved. Given that context we decided to treat the patients with C5 blocker Eculizumab and obtain an extraordinary positive response. |
| Databáze: | OpenAIRE |
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