Relationship between human leukocyte antigen DRB1 and psoriasis in Iraqi patients
| Autor: | Batool Mutar Mahdi, Haider Hashim Zalzala, Hyam R. Mohammedsalih, Mohammed Y. Abbas, Galawish A. Abdullah |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Adolescent Genotype Cross-sectional study Human leukocyte antigen Polymerase Chain Reaction 03 medical and health sciences Young Adult Psoriasis Internal medicine medicine Humans Genetic Predisposition to Disease Young adult Child Genotyping business.industry Case-control study General Medicine Odds ratio Middle Aged medicine.disease 030104 developmental biology Cross-Sectional Studies Case-Control Studies Child Preschool Iraq Original Article Female business HLA-DRB1 Chains |
| Zdroj: | Saudi Medical Journal |
| ISSN: | 0379-5284 |
| Popis: | Objectives: To investigate the role of Human leukocyte antigen ( HLA) Class II DRB1 in susceptibility to psoriasis in Iraqi patients. Methods: A cross-sectional comparative study including 40 patients with psoriasis attending the Department of Dermatology, Al-Kindy teaching hospital in Baghdad, Iraq, between September 2013-2015. Patient selection was carried out by the dermatologists. Ninety healthy individuals were included in the study. Human leukocyte antigen genotyping was carried out by the sequence specific oligonucleotide (SSO) method using Auto LiPA 48 (Innogenetics, Belgium) in the HLA typing research unit of the Al-Kindy College of Medicine, Baghdad, Iraq. Results: There is an increased frequency of HLA-DRB1*0102, *0306 in psoriatic patients with psoriasis p -values=0.001, confidence interval(CI)=2.492-37.487 and odds ratio(OR)=9.666. Human leukocyte antigen - DRB1*1101 is significantly associated with plaque-type psoriasis with p =0.0434, CI=1.04-1.69, and OR=4.2. Human leukocyte antigen - DRB1*0102 is significantly associated with other types of psoriasis with p =0.018, CI=0.0223-0.701, and OR=0.125. Conclusion: Human leukocyte antigen-DRB1*0102 and *0306 are significantly associated with psoriasis. Human leukocyte antigen-DRB1*1101 is significantly associated with plaque-type psoriasis. Human leukocyte antigen-DRB1*0102 is significantly associated with other types of psoriasis rather than plaque-type psoriasis. |
| Databáze: | OpenAIRE |
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