Carbohydrate and lipid metabolism in multiple sclerosis: Clinical implications for etiology, pathogenesis, diagnosis, prognosis, and therapy
| Autor: | Seyyed Mortaza Haghgoo, Pantea Mohammadi, Reza Yarani, Mohammad Sajad Emami Aleagha, Somayeh Pashaei |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Autoimmune disease
Multiple Sclerosis business.industry Multiple sclerosis Central nervous system Biophysics Lipid metabolism medicine.disease Bioinformatics Lipid Metabolism Prognosis Biochemistry Pathophysiology Pathogenesis Immune system medicine.anatomical_structure Immune System medicine Etiology Animals Carbohydrate Metabolism Humans business Molecular Biology |
| Zdroj: | Archives of biochemistry and biophysics. 712 |
| ISSN: | 1096-0384 |
| Popis: | Multiple sclerosis (MS) is a complicated autoimmune disease characterized by inflammatory and demyelinating events in the central nervous system. The exact etiology and pathogenesis of MS have not been elucidated. However, a set of metabolic changes and their effects on immune cells and neural functions have been explained. This review highlights the contribution of carbohydrates and lipids metabolism to the etiology and pathogenesis of MS. Then, we have proposed a hypothetical relationship between such metabolic changes and the immune system in patients with MS. Finally, the potential clinical implications of these metabolic changes in diagnosis, prognosis, and discovering therapeutic targets have been discussed. It is concluded that research on the pathophysiological alterations of carbohydrate and lipid metabolism may be a potential strategy for paving the way toward MS treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect