| Autor: |
Fuxin, Zhang, Huanhuan, Liu, Kailing, Yang, Tao, Yang, Ruixi, Zhou, Rongkun, Miao, Guanqun, Zhan, Zengjun, Guo |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Fitoterapia. 158:105143 |
| ISSN: |
0367-326X |
| DOI: |
10.1016/j.fitote.2022.105143 |
| Popis: |
Two new phenylpropanoids (1-2), one new nor-monoterpenoid alkaloid (3), one new monoterpene alkaloid (4), together with nine known compounds (5-13) were obtained from the branches of Alstonia scholaris. The structures of the undescribed compounds were determined by extensive spectroscopic analysis. Alkaloid 3 represented the first example of C-4 methylated nor-monoterpenoid alkaloids. A possible biosynthetic pathway for this new type of monoterpene alkaloids was proposed. All the isolates were evaluated for vasorelaxant activity against phenylephrine-induced contraction of rat mesenteric arteries. Compounds 1, 4, 9, 12, and 13 showed significant vasorelaxant activity with relaxation rates above 90% at 200 μM and exhibited moderate vasorelaxant activity with IC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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