Effect of hemorheological parameters on myocardial injury after primary or elective percutaneous coronary intervention
| Autor: | Alessandro Mandurino-Mirizzi, Patrizia Caprari, Serena Panicale, Giampaolo Niccoli, Filippo Crea, Vincenzo Vetrugno, Francesco Fracassi, Nicola Cosentino |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Erythrocyte Aggregation
Male medicine.medical_specialty Time Factors medicine.medical_treatment Blood viscosity 030204 cardiovascular system & hematology Coronary Angiography Angina Electrocardiography Necrosis 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Risk Factors Internal medicine Humans Medicine Angina Stable Prospective Studies cardiovascular diseases 030212 general & internal medicine Myocardial infarction Non-ST Elevated Myocardial Infarction Prospective cohort study Aged Aged 80 and over medicine.diagnostic_test business.industry Myocardium Percutaneous coronary intervention General Medicine Middle Aged Blood Viscosity medicine.disease Treatment Outcome Hemorheology Conventional PCI Cardiology ST Elevation Myocardial Infarction Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Coronary Artery Disease. 29:638-646 |
| ISSN: | 0954-6928 |
| DOI: | 10.1097/mca.0000000000000661 |
| Popis: | BACKGROUND Abnormal blood viscosity favors atherosclerosis owing to endothelial dysfunction and changes in shear stress. Its effect on coronary microvasculature during percutaneous coronary intervention (PCI) is still unknown. We aimed to investigate the role of hemorheological parameters in the incidence of microvascular obstruction (MVO) and the periprocedural necrosis after primary or elective PCI, and secondarily, we evaluated their prognostic significance. MATERIALS AND METHODS We enrolled 25 patients with ST-elevation myocardial infarction (STEMI), 30 patients with non-ST-elevation myocardial infarction (NSTEMI), and 30 patients with stable angina (SA) undergoing PCI. MVO in patients with STEMI and periprocedural necrosis in patients with NSTEMI and those with SA were assessed using angiographic/electrocardiographic and laboratory methods, respectively. Hemorheological profile included blood viscosity (η) at shear rates 200 s and 1 s, the erythrocyte aggregation index (η1/η200), and plasma viscosity. Major adverse cardiovascular events occurrence was evaluated at follow-up. RESULTS Patients with STEMI experiencing angiographic MVO (28%) had higher η200 (5.42±1.28 vs. 3.98±1.22 mPa[BULLET OPERATOR]s; P=0.015). Similarly, patients with STEMI experiencing electrocardiographic MVO (56%) had higher η200 (4.58±0.36 vs. 3.94±0.19 mPa[BULLET OPERATOR]s; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|