One-Pot Multicomponent Synthesis of β-Amino Amides

Autor:	Sunliang Cui, Linwei Zeng, Yangyong Shen, Bo Huang
Rok vydání:	2017
Předmět:	Molecular complexity Aldehydes Reaction mechanism Aniline Compounds Molecular Structure Chemistry 010405 organic chemistry Carboxylic Acids Stereoisomerism General Chemistry General Medicine 010402 general chemistry Amides Combinatorial chemistry Small molecule 01 natural sciences Catalysis 0104 chemical sciences Chemical diversity Scientific method
Zdroj:	Angewandte Chemie. 129:4636-4639
ISSN:	0044-8249
DOI:	10.1002/ange.201700840
Popis:	Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one-pot multicomponent synthesis of β-amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.
Databáze:	OpenAIRE
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