Metformin Pharmacogenetics: Effects of SLC22A1, SLC22A2, and SLC22A3 Polymorphisms on Glycemic Control and HbA1c Levels
| Autor: | Laith N. AL-Eitan, Ahmad M. Nassar, Barakat Z Elsaqa, Nesreen A. Saadeh, Basima A. Almomani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
HbA1c endocrine system diseases lcsh:Medicine Medicine (miscellaneous) 030209 endocrinology & metabolism Single-nucleotide polymorphism 030204 cardiovascular system & hematology Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine SNP Glycemic pharmacogenetics solute carrier gene business.industry lcsh:R Type 2 Diabetes Mellitus nutritional and metabolic diseases Metformin SNP genotyping glycemic control business metformin Body mass index Pharmacogenetics medicine.drug SNPs |
| Zdroj: | Journal of Personalized Medicine Volume 9 Issue 1 Journal of Personalized Medicine, Vol 9, Iss 1, p 17 (2019) |
| ISSN: | 2075-4426 1219-4182 |
| DOI: | 10.3390/jpm9010017 |
| Popis: | Type 2 diabetes mellitus (T2DM) constitutes a major portion of Jordan&rsquo s disease burden, and incidence rates are rising at a rapid rate. Due to variability in the drug&rsquo s response between ethnic groups, it is imperative that the pharmacogenetics of metformin be investigated in the Jordanian population. The objective of this study was to investigate the relationship between twenty-one single nucleotide polymorphisms (SNPs) in the SLC22A1, SLC22A2, and SLC22A3 genes and their effects on metformin pharmacogenetics in Jordanian patients diagnosed with type 2 diabetes mellitus. Blood samples were collected from 212 Jordanian diabetics who fulfilled the inclusion criteria, which were then used in SNP genotyping and determination of HbA1c levels. The rs12194182 SNP in the SLC22A3 gene was found to have a significant association (p < 0.05) with lower mean HbA1c levels, and this association more pronounced in patients with the CC genotype (i.e., p-value was significant before correcting for multiple testing). Moreover, the multinomial logistic regression analysis showed that SNP genotypes within the SLC22A1, SLC22A2, and SLC22A3 genes, body mass index (BMI) and age of diagnosis were significantly associated with glycemic control (p < 0.05). The results of this study can be used to predict response to metformin and other classes of T2DM drugs, making treatment more individualized and resulting in better clinical outcomes. |
| Databáze: | OpenAIRE |
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