A secreted antibacterial neuropeptide shapes the microbiome of Hydra
| Autor: | Andrea P. Murillo Rincón, Eva-Maria Herbst, Jörg Wittlieb, Friederike Anton-Erxleben, Martin Schwentner, Trudy M. Wassenaar, René Augustin, Sebastian Fraune, Thomas C. G. Bosch, Katja Schröder, Joachim Grötzinger |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hydra Science ved/biology.organism_classification_rank.species General Physics and Astronomy Neuropeptide Ectoderm Biology Gram-Positive Bacteria General Biochemistry Genetics and Molecular Biology Epithelium Article Comamonadaceae 03 medical and health sciences 0302 clinical medicine medicine Animals Secretion Microbiome Model organism lcsh:Science Neurons Multidisciplinary ved/biology Ecology Microbiota Neuropeptides General Chemistry Cell biology Anti-Bacterial Agents 030104 developmental biology medicine.anatomical_structure Neuroimmunology Lernaean Hydra lcsh:Q 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Colonization of body epithelial surfaces with a highly specific microbial community is a fundamental feature of all animals, yet the underlying mechanisms by which these communities are selected and maintained are not well understood. Here, we show that sensory and ganglion neurons in the ectodermal epithelium of the model organism hydra (a member of the animal phylum Cnidaria) secrete neuropeptides with antibacterial activity that may shape the microbiome on the body surface. In particular, a specific neuropeptide, which we call NDA-1, contributes to the reduction of Gram-positive bacteria during early development and thus to a spatial distribution of the main colonizer, the Gram-negative Curvibacter sp., along the body axis. Our findings warrant further research to test whether neuropeptides secreted by nerve cells contribute to the spatial structure of microbial communities in other organisms. Certain neuropeptides, in addition to their neuromodulatory functions, display antibacterial activities of unclear significance. Here, the authors show that a secreted neuropeptide modulates the distribution of bacterial communities on the body surface during development of the model organism Hydra. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|