Am I hallucinating or is my fusiform cortex activated? Functional activation differences in schizophrenia patients with and without hallucinations
| Autor: | Philipp Homan, Claudia van Swam, Daniela Hubl, Thomas Dierks, Katharina Kunzelmann, Matthias Grieder, Stephanie Winkelbeiner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Fusiform gyrus medicine.diagnostic_test business.industry Inferior frontal gyrus Magnetic resonance imaging Audiology behavioral disciplines and activities Lateralization of brain function Psychiatry and Mental health Superior temporal gyrus Hallucinating medicine Verbal fluency test Functional magnetic resonance imaging business 610 Medicine & health |
| DOI: | 10.7892/boris.120748 |
| Popis: | Background and Objectives Auditory verbal hallucinations (AVH) as well as aberrant language functioning, i.e. deficits in verbal fluency (VF) are common symptoms in patients with schizophrenia. The relationship between deficits in VF and AVH is rarely studied. In previous imaging studies, activation patterns during VF differed between patients with schizophrenia and healthy controls, independent of AVH phenomenology. However, activation patterns were not investigated for patients with and without AVH in separate groups. We hypothesized that there would be a difference in activation patterns between healthy controls and patients with schizophrenia, but not between hallucinating and non-hallucinating patients. Methods In the current study, we included 31 participants in three groups: patients with schizophrenia and AVH, patients with schizophrenia without AVH, and healthy controls without AVH. All subjects performed a VF task while functional activation was measured by blood-oxygen-level-dependent (BOLD) magnetic resonance imaging (MRI). Task-dependent activation was compared between the three groups. Results and Conclusions All three groups showed activation in language areas of the brain, such as Broca’s area, located in the inferior frontal gyrus, or Wernicke’s area, located in the superior temporal gyrus. Patients had significant task-specific activation in the right hemisphere in addition to activation in language-related areas in the left hemisphere. Unexpectedly, we found significantly more activation in the bilateral fusiform gyrus of non-hallucinating compared to hallucinating patients. It seemed that fusiform gyrus activation serves as a strategy to compensate for performance deficits, significantly more in patients without AVH than in those with AVH. |
| Databáze: | OpenAIRE |
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