Dynamic alteration of serum testosterone with aging: a cross-sectional study from Shanghai, China
| Autor: | Lihong Wang, Zhangshun Liu, Yan Yang, Minfang Tao, Xiaohong Shi, Jie Liu |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male Aging China medicine.medical_specialty Cross-sectional study medicine.drug_class Reproductive medicine Androgen Young Adult Endocrinology Adult male Internal medicine Humans Medicine Testosterone Shanghai china Young adult Aged Aged 80 and over Serum testosterone business.industry Research Reproductive hormones Obstetrics and Gynecology Testosterone (patch) Middle Aged Cross-Sectional Studies Reproductive Medicine business Biomarkers Developmental Biology |
| Zdroj: | Reproductive Biology and Endocrinology : RB&E |
| ISSN: | 1477-7827 |
| DOI: | 10.1186/s12958-015-0107-z |
| Popis: | Background Level of the testosterone in a man’s life span is very important. Studies on the serum testosterone concentrations in different age groups of healthy men were controversial. The aim of this study was to investigate dynamic changes of serum reproductive hormones with aging in healthy Chinese male and to compare its correlation with age. Methods Total of 1,093 healthy Chinese men from Shanghai aged from 20 to 87 years old was enrolled in the study. Concentrations of serum total testosterone (T), luteinizing hormone (LH) and sex hormone binding globulin (SHBG) were quantified by EIA. Testosterone secretion index (TSI) and free testosterone index (FTI) were then calculated. Data were analyzed by SPSS program. Non-parametric tests and univariate linear regression analyses were used. Results The 1,039 male participants were grouped into 12 groups by 5-year apart for each group. Significant differences in T, LH, SHBG, FTI and TSI were found between the 12 different age groups. Average of serum total T was 15.36 ± 4.86 nmol/L; LH was 4.76 ± 2.76 IU/L, SHBG was 32.61 ± 17.24 nmol/L. Compared to age 20 ~ 24 group, serum T level of age 35 ~ 39, 40 ~ 44, 45 ~ 49, 50 ~ 54, and 55 ~ 59 was significantly decreased (p |
| Databáze: | OpenAIRE |
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