Caffeine-related effects on cognitive performance: Roles of apoptosis in rat hippocampus following sleep deprivation

Autor: Xiaoyu Huang, Ping Wang, Hao Li, Panpan Huang, Guangjing Xie
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
medicine.medical_treatment
Biophysics
Spatial Learning
Hippocampus
Apoptosis
Hippocampal formation
Motor Activity
Biochemistry
Rats
Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cognition
Internal medicine
Caffeine
Medicine
Animals
Humans
Cognitive Dysfunction
Effects of sleep deprivation on cognitive performance
Molecular Biology
Nootropic Agents
Dose-Response Relationship
Drug
business.industry
Pyramidal Cells
Cell Biology
Mitochondria
Rats
Stimulant
Arginine Vasopressin
Sleep deprivation
Disease Models
Animal
030104 developmental biology
Endocrinology
chemistry
030220 oncology & carcinogenesis
Sleep Deprivation
Central Nervous System Stimulants
medicine.symptom
business
Neurocognitive
Signal Transduction
Vasoactive Intestinal Peptide
Zdroj: Biochemical and biophysical research communications. 534
ISSN: 1090-2104
Popis: Caffeine is a common stimulant widely existed in food and has stimulatory effects on the central nervous system, shift-work individuals often rely on caffeine to maintain attention and keep awake. Although sleep deprivation (SD) is widely considered as an independent risk factor for cognition retardations, however, little is well understood about the synergistic role of caffeine dosage and SD for cognitive performance. This research intended to investigate the underlying molecular mechanism of varying caffeine doses on cognitive function after sleep deprivation. The results revealed that SD attenuated the cognitive dysfunction, associated with ultrastructure damage and pyramidal neuron loss in the hippocampus, decreased in the level of VIP and AVP. SD also significantly accelerated the neuropeptide-associated apoptosis in the hippocampus, which may modulate via the cAMP-PKA-CREB signal path axis and activation of the downstream apoptosis genes. Additionally, the data indicated that low-dose caffeine (LC) contributed to cognitive enhancement, and high-dose caffeine (HC) aggravated cognitive impairment by modulating hippocampal neuronal apoptosis. Our studies suggest that caffeine, particularly in high dosage, may be a potential factor to influence the neurocognitive outcome caused by sleep loss, and the appropriate amount of caffeine ingested after sleep deprivation deserves serious consideration.
Databáze: OpenAIRE
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