The antiviral potency of Fagus sylvatica 4OMe-glucuronoxylan sulfates
| Autor: | Elsa B. Damonte, Peter Capek, Jozef Turjan, K. Z. Yanbo, Carlos A. Pujol |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
CIENCIAS MÉDICAS Y DE LA SALUD viruses Ciencias de la Salud 02 engineering and technology Biology medicine.disease_cause Antiviral Agents Biochemistry Herpesviridae Dengue fever Microbiology 03 medical and health sciences Sulfation Structural Biology Glucuronoxylan Chlorocebus aethiops Fagus medicine Animals Potency 4OME-GLUCURONOXYLAN SULFATES Vero Cells Molecular Biology chemistry.chemical_classification Salud Ocupacional Molecular mass Sulfates ANTIVIRAL ACTIVITY General Medicine 021001 nanoscience & nanotechnology medicine.disease Virology 030104 developmental biology Herpes simplex virus chemistry Viruses Vero cell Xylans 0210 nano-technology HERPES SIMPLEX VIRUS |
| Zdroj: | International Journal of Biological Macromolecules. 87:195-200 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2016.02.048 |
| Popis: | Herpes simplex virus belongs to Herpesviridae family and causes infection of humans from ancient times. 4OMe-glucuronoxylans as the renewable biopolymers can be promising glycomaterials for various applications in pharmacy. Control enzymatic degradation of the native 4OMe-glucuronoxylan (GX1) followed by targeted sulfation procedure afforded a range of 4OMe-glucuronoxylan sulfates differed in the degree of sulfation (10-16%) and molecular mass (21,000-5000 g/mol; GXS1 > GXS2 > GXS3 > GXS4). Antiviral activity tests on GXS1-4 against herpes simplex virus (HSV) types 1 and 2 revealed the positive effect of all compounds against strains of herpes virus. Of them, the compounds GXS1 and GXS4 were shown to be the most active for both HSV serotypes. The antiviral activity of GXS1 and GXS4 was similar to those of heparin or dextran sulfate, used as reference compounds. It was found that GXS1 and GXS4 were active as well against Polio and dengue viruses, however, on a smaller scale. The mode of antiviral action of 4OMe-glucuronoxylan sulfates is due to inhibition of the virus binding to the cell receptors. Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Turjan, J. Slovak Academy of Sciences; Eslovaquia Fil: Yanbo, K. Z.. University of Hong Kong; Hong Kong Fil: Capek, P.. Slovak Academy of Sciences; Eslovaquia |
| Databáze: | OpenAIRE |
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