Biomimetic hydrogels with spatial- and temporal-controlled chemical cues for tissue engineering
| Autor: | Rupak M. Rajachar, Weilue He, Max Reaume, Maureen Hennenfent, Bruce P. Lee |
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| Rok vydání: | 2020 |
| Předmět: |
Cell signaling
Tissue Engineering Tissue Scaffolds Chemistry Bioactive molecules Biomedical Engineering technology industry and agriculture Nanotechnology Hydrogels complex mixtures Tissue engineering scaffold Article Regulatory molecules Drug Liberation Tissue engineering Biomimetic Materials Self-healing hydrogels Animals Humans Intercellular Signaling Peptides and Proteins General Materials Science |
| Zdroj: | Biomater Sci |
| ISSN: | 2047-4849 |
| Popis: | Biomimetic hydrogels have emerged as the most useful tissue engineering scaffold materials. Their versatile chemistry can recapitulate multiple physical and chemical features to integrate cells, scaffolds, and signaling molecules for tissue regeneration. Due to their highly hydrophilic nature hydrogels can recreate nutrient-rich aqueous environments for cells. Soluble regulatory molecules can be incorporated to guide cell proliferation and differentiation. Importantly, the controlled dynamic parameters and spatial distribution of chemical cues in hydrogel scaffolds are critical for cell–cell communication, cell-scaffold interaction, and morphogenesis. Herein, we review biomimetic hydrogels that provide cells with spatiotemporally controlled chemical cues as tissue engineering scaffolds. Specifically, hydrogels with temporally controlled growth factor-release abilities, spatially controlled conjugated bioactive molecules/motifs, and targeting delivery and reload properties for tissue engineering applications are discussed in detail. Examples of hydrogels that possess clinically favorable properties, such as injectability, self-healing ability, stimulus-responsiveness, and pro-remodeling features, are also covered. |
| Databáze: | OpenAIRE |
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