Radioiodine Therapy for Multinodular Toxic Goiter
| Autor: | Jens Mølholm Hansen, Laszlo Hegedüs, Kamilla Gerhard Nielsen, Peter S. Ulriksen, Birte Nygaard |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty Goiter endocrine system diseases medicine.medical_treatment chemistry.chemical_element Iodine Thyroid function tests Gastroenterology Effective dose (radiation) Iodine Radioisotopes Internal medicine Internal Medicine medicine Humans Life Tables Euthyroid Prospective Studies Aged Aged 80 and over medicine.diagnostic_test business.industry Antithyroid agent Thyroid Middle Aged medicine.disease Treatment Outcome medicine.anatomical_structure chemistry Female Thyroid function business Nuclear medicine Algorithms Goiter Nodular |
| Zdroj: | Archives of Internal Medicine. 159:1364 |
| ISSN: | 0003-9926 |
| Popis: | Background: Radiolabeled iodine 131 therapy is used for treatment of multinodular toxic goiter, but long-term follow-up studies are lacking. Methods: A prospective study of 130 consecutive patients (115 women) treated with 131 I for multinodular toxic goiter and followed by evaluation of thyroid volume (determined using ultrasound) and thyroid function variables. Results: The patients were observed for a median of 72 months (range, 12-180 months). Sixty-six patients received antithyroid drug pretreatment; 64 did not. Iodine 131 treatment (3.7 MBq/g thyroid tissue corrected to a 100% 24-hour 131 I uptake) was given as a single dose in 81 patients, 2 doses in 38, and 3 to 5 doses in 11. One or 2 treatments cured 119 patients (92%), and 68 (52%) became euthyroid within 3 months after 1 131 I treatment. The median 131 I dose was 370 MBq (range, 93-1850 MBq). Forty-nine patients needing more than 1 131 I dose had a reduction in median thyroid volume from 56 mL (range, 21-430 mL) to 44 mL (range, 15-108 mL), representing a 24% reduction related to the insufficient 131 I dose. In all patients, the initial median thyroid volume of 44 mL (range, 16-430 mL) decreased to 25 mL (range, 8-120 mL) (P |
| Databáze: | OpenAIRE |
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