The application of color Doppler flow imaging in the diagnosis and therapeutic effect evaluation of erectile dysfunction
| Autor: | Cong-Hui Han, Jun Chen, Xu-Jun Xuan, Ma Gang, Chao Xu, Fu-Ding Lu, Cai-Xia Zhang, Yang Peng, Bai Gang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty penis rigidity color Doppler flow imaging Lidocaine Sildenafil erectile dysfunction Urology sildenafil 030232 urology & nephrology Diastole Hemodynamics lcsh:RC870-923 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine medicine Humans Ultrasonography Doppler Color Aged Papaverine 030219 obstetrics & reproductive medicine business.industry Therapeutic effect General Medicine Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology Surgery Erectile dysfunction chemistry cGMP-specific phosphodiesterase type 5 Original Article business hemodynamic parameters medicine.drug |
| Zdroj: | Asian Journal of Andrology, Vol 18, Iss 1, Pp 118-122 (2016) Asian Journal of Andrology |
| ISSN: | 1745-7262 |
| Popis: | We aim to investigate the correlations between hemodynamic parameters, penile rigidity grading, and the therapeutic effects of phosphodiesterase type 5 inhibitors using color Doppler flow imaging after intracavernosal injection in patients with erectile dysfunction. This study involved 164 patients. After intracavernosal injection with a mixture of papaverine (60 mg), prostaglandin E1 (10 μg), and lidocaine (2%, 0.5–1 ml), the penile vessels were assessed using color Doppler flow imaging. Penile rigidity was classified based on the Erection Hardness Score system as Grades 4, 3, 2 or 1 (corresponding to Schramek Grades V to II). Then, the patients were given oral sildenafil (50–100 mg) and scored according to the International Index of Erectile Function (IIEF-5) questionnaire. The number of patients with penile rigidities of Schramek Grades II to V was 14, 18, 21, and 111, respectively. The IIEF-5 score was positively correlated with the refilling index of the penile cavernosal artery (r = 0.79, P < 0.05), the peak systolic velocity (r = 0.45, P < 0.05), and penile rigidity (r = 0.75, P < 0.05), and was negatively correlated with the end diastolic velocity (r = −0.74, P < 0.05). For patients with erectile dysfunction, both the IIEF-5 score after sildenafil administration, which is correlated with penile rigidity, and the hemodynamic parameters detected using color Doppler flow imaging may predict the effects of phosphodiesterase type 5 inhibitor treatment and could provide a reasonable model for the targeted-treatment of erectile dysfunction. |
| Databáze: | OpenAIRE |
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