Rapid resolution of choroidal metastatic tumour secondary to lung cancer following treatment with alectinib
| Autor: | May Thu Han, Benjamin J L Burton, Deborah Busby, Ahmed Al-Janabi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Alectinib medicine.medical_specialty Lung Neoplasms Visual acuity genetic structures Carbazoles Case Report Fundus (eye) 03 medical and health sciences 0302 clinical medicine Piperidines Swallowing Carcinoma Non-Small-Cell Lung medicine Humans Lung cancer business.industry Choroid Neoplasms General Medicine Middle Aged medicine.disease eye diseases Posterior segment of eyeball Chronic cough 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Abnormal Liver Function Test sense organs Radiology medicine.symptom business |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2020-238573 |
| Popis: | A 64-year-old man presented with reduced vision in the right eye (visual acuity of 6/24 Snellen). The patient reported having a chronic cough and recent weight loss with difficulty in swallowing and abnormal liver function test 8 months prior to his presentation. He was a chronic smoker for 45 years, having quit a year earlier. Fundus examination showed a unifocal large yellow–brown subretinal mass involving the posterior segment of the eye and associated with subretinal fluid. The patient was diagnosed with a choroidal metastasis and was referred urgently to the oncology team who confirmed the presence of non-small cell lung cancer with distant metastases. He started treatment with alectinib (second-generation tyrosine kinase inhibitor). A few weeks later, his vision improved and, on examination, there was complete resolution of the choroidal mass and the associated subretinal fluid. Alectinib led to rapid resolution of his choroidal secondary and has excellent ocular safety profile. |
| Databáze: | OpenAIRE |
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