Survival outcomes in men with a positive family history of prostate cancer: a registry based study
| Autor: | Michael O'Callaghan, Mann Ang, Martin Borg |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Survival medicine.medical_treatment Family history 030232 urology & nephrology Outcomes lcsh:RC254-282 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine medicine Genetics Humans Registries Medical History Taking Aged business.industry Prostatectomy Prostate Cancer Confounding Cancer Prostatic Neoplasms Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Survival Analysis Log-rank test Radiation therapy Treatment Outcome Lead time bias 030220 oncology & carcinogenesis business Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020) |
| ISSN: | 1471-2407 |
| Popis: | Background To investigate the correlation between family history of prostate cancer (PCa) and survival (overall and cancer specific) in patients undergoing treatment for PCa. Methods ine thousand four hundred fifty-nine patients with PCa were extracted from the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database. Diagnosis occurred after 1998 and treatment before 2014. Cox proportional-hazards modeling was used to assess the effect of family history on overall survival after adjustment for confounders (age at diagnosis, NCCN risk category and year of treatment), and with stratification by primary treatment group. Competing risks regression modelling was used to assess PCa specific mortality. Results Men with a positive family history of PCa appear to have a lower Gleason score at the time of diagnosis (50% with Gleason p p = 0.021). There were no significant differences in treatment subgroups of radical prostatectomy (p = 0.7) and radiotherapy (0.054). Conclusion Men with a positive family history of PCa appear to have better overall survival outcomes. This better survival may represent lead time bias and early initiation of PSA screening. Family history of PCa was not associated with different survival outcomes in men who were treated with either radical prostatectomy or radiotherapy. |
| Databáze: | OpenAIRE |
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