Whey proteins influence hepatic glutathione after CCl4 intoxication
| Autor: | Emanuela Balbis, Samir Giuseppe Sukkar, Nicola Traverso, Stefania Patriarca, Anna Lisa Furfaro, Maria Adelaide Pronzato, Damiano Cottalasso, S Millanta, Umberto M. Marinari |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Whey protein medicine.medical_specialty Liquid diet Health Toxicology and Mutagenesis CCL4 Oxidative phosphorylation Toxicology medicine.disease_cause Rats Sprague-Dawley chemistry.chemical_compound Internal medicine Casein medicine Animals Carbon Tetrachloride Poisoning Chemistry Public Health Environmental and Occupational Health Caseins Glutathione Milk Proteins Rats Oxidative Stress Whey Proteins Endocrinology Liver Biochemistry Carbon tetrachloride Chemical and Drug Induced Liver Injury Oxidative stress |
| Zdroj: | Toxicology and Industrial Health. 25:325-328 |
| ISSN: | 1477-0393 0748-2337 |
| DOI: | 10.1177/0748233709104870 |
| Popis: | Whey proteins (WP) are known to contain more cysteine than casein (CAS), so it is suggested that they should ameliorate the oxidative equilibrium in the organisms. To evaluate the influence of a WP-based diet on liver glutathione (GSH) content, male Sprague-Dawley rats were fed for 3 weeks a balanced liquid diet containing either WP or CAS as main source of protein. Liver GSH content was evaluated at the end of the treatment by high performance liquid chromatography (HPLC), both in basal conditions and after oxidative stress induced by CCl4 acute intoxication. In basal conditions, WP diet significantly increased hepatic GSH in comparison to CAS diet. After CCl4 intoxication, hepatic GSH was negligibly increased in CAS group, while its increase was much more marked in WP group, so that the difference between the two diets was significant; this suggests that WP provided rats with better ability to increase their GSH synthesis in case of need. |
| Databáze: | OpenAIRE |
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