A Rapid-mix Study on the Effect of Lipophilicity of Nitroimidazoles on the Radiosensitization of Mammalian Cellsin Vitro
| Autor: | Richard J. Hodgkiss, N.R. Jones, M. Woodcock, M.E. Watts, D.S. Sehmi |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Octanol
Radiation-Sensitizing Agents Cell Survival Chemistry Diffusion Free base Dose-Response Relationship Radiation General Medicine In vitro Cell Line Partition coefficient chemistry.chemical_compound medicine.anatomical_structure Target site Nitroimidazoles Cricetinae Lipophilicity Biophysics medicine Animals Misonidazole Sensitization |
| Zdroj: | International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. 43:329-336 |
| ISSN: | 0020-7616 |
| Popis: | A liquid flow rapid-mixing apparatus has been used to study the role of lipophilicity (octanol: water partition coefficient, P) in the sensitization of hypoxic V79 cells by nitroimidazoles. Sensitization by seven neutral 2-nitroimidazoles of similar reduction potential but widely differing partition (0.11-77) and one basic 2-nitroimidazole (pKa=8.9; p=8.5 (of free base)) was studied as a function of pre-irradiation contact time ca. 3-40 ms. With increasing P, sensitization occurs at increasingly shorter pre-irradiation contact times. The results suggest that even though factors other than passive diffusion control the sensitization observed with the base Ro 03-8799 it is able to diffuse to the target site faster than midonidazole. |
| Databáze: | OpenAIRE |
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