TY-12533, a novel Na+/H+ exchange inhibitor, prevents myocardial stunning in dogs
| Autor: | Susumu Satoh, Fuminari Yamaguchi, Fumiya Yoneyama, Hiroaki Hisa, Isamu Satoh, Jun Sasamori, Kazuyuki Aihara |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Sodium-Hydrogen Exchangers Pyridines medicine.medical_treatment Ischemia Guanidines Dogs Coronary Circulation medicine Carnivora Animals Acidosis Myocardial Stunning Pharmacology Myocardial stunning Chemotherapy biology business.industry Vascular disease Myocardium Fissipedia Heart Blood flow Hydrogen-Ion Concentration biology.organism_classification medicine.disease Anesthesia Female medicine.symptom business Anti-Arrhythmia Agents |
| Zdroj: | European Journal of Pharmacology. 419:93-97 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(01)00952-9 |
| Popis: | Anesthetized open-chest dogs were subjected to 15-min myocardial ischemia followed by 2-h reperfusion to induce myocardial stunning. A novel Na(+)/H(+) exchange inhibitor 6,7,8,9-tetrahydro-2-methyl-5H-cyclohepta[b]pyridine-3-carbonylguanidine maleate (TY-12533), administered 10 min before or 10 min after start of ischemia (3 mg/kg/10 min, i.v.), did not affect reductions in regional myocardial wall thickening, blood flow and pH during ischemia, but it significantly improved recovery of the wall thickening and blood flow after reperfusion. These results indicate that TY-12533, even when administered during ischemia, could prevent myocardial stunning without affecting myocardial dysfunction or acidosis induced by brief ischemia. |
| Databáze: | OpenAIRE |
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