Iota-Carrageenan Is a Potent Inhibitor of Influenza A Virus Infection
| Autor: | Regina Weinmüllner, Philipp Graf, Martin Beer, Britta Frank-Gehrke, Christiane Meier, Hermann Unger, Andreas Leibbrandt, Andreas Grassauer, Donata Kalthoff, Marielle König-Schuster, Tamas Fazekas, Eva Prieschl-Grassauer, Bettina Pflugfelder |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Oseltamivir
Magnetic Resonance Spectroscopy Polymers medicine.medical_treatment viruses lcsh:Medicine Neuraminidase Drug resistance medicine.disease_cause Carrageenan Antiviral Agents Microbiology chemistry.chemical_compound Mice Dogs Polysaccharides Pandemic Drug Resistance Viral Influenza Human medicine Influenza A virus Animals Humans Enzyme Inhibitors lcsh:Science Virology/Antivirals including Modes of Action and Resistance Multidisciplinary biology Lethal dose lcsh:R virus diseases respiratory system Virology In vitro Virology/New Therapies including Antivirals and Immunotherapy respiratory tract diseases Mice Inbred C57BL Disease Models Animal chemistry Nasal spray biology.protein Virology/Animal Models of Infection lcsh:Q Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 5, Iss 12, p e14320 (2010) |
| ISSN: | 1932-6203 |
| Popis: | The 2009 flu pandemic and the appearance of oseltamivir-resistant H1N1 influenza strains highlight the need for treatment alternatives. One such option is the creation of a protective physical barrier in the nasal cavity. In vitro tests demonstrated that iota-carrageenan is a potent inhibitor of influenza A virus infection, most importantly also of pandemic H1N1/2009 in vitro. Consequently, we tested a commercially available nasal spray containing iota-carrageenan in an influenza A mouse infection model. Treatment of mice infected with a lethal dose of influenza A PR8/34 H1N1 virus with iota-carrageenan starting up to 48 hours post infection resulted in a strong protection of mice similar to mice treated with oseltamivir. Since alternative treatment options for influenza are rare, we conclude that the nasal spray containing iota-carrageenan is an alternative to neuraminidase inhibitors and should be tested for prevention and treatment of influenza A in clinical trials in humans. |
| Databáze: | OpenAIRE |
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