Custom-Made Zirconium Dioxide Implants for Craniofacial Bone Reconstruction
| Autor: | Marcin Kozakiewicz, Bartłomiej Konieczny, Radosław Zajdel, Tomasz Gmyrek |
|---|---|
| Přispěvatelé: | Department of Informatics and Statistics, Medical University in Lodz, Pl. Hallera 1, 90-647 Łódź, Poland, Department of Maxillofacial Surgery, Medical University of Lodz, 113 Zeromskiego Str, 90-549 Lodz, Poland, University Laboratory of Materials Research, Medical University of Lodz, 251 Pomorska, 92-213 Lodz, Poland |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
titanium alloy
bone defect treatment maxillofacial surgery craniofacial lcsh:Technology Osseointegration Article 03 medical and health sciences ultrahigh molecular weight polyethylene 0302 clinical medicine medicine General Materials Science Craniofacial 030223 otorhinolaryngology lcsh:Microscopy Craniofacial surgery lcsh:QC120-168.85 lcsh:QH201-278.5 business.industry lcsh:T genotoxicity Soft tissue Osteoblast 030206 dentistry custom implants Resorption medicine.anatomical_structure lcsh:TA1-2040 Facial skeleton zirconium dioxide cytotoxicity lcsh:Descriptive and experimental mechanics Implant lcsh:Electrical engineering. Electronics. Nuclear engineering business lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 Biomedical engineering |
| Zdroj: | Materials Materials, Vol 14, Iss 840, p 840 (2021) Volume 14 Issue 4 |
| ISSN: | 1996-1944 |
| Popis: | Reconstruction of the facial skeleton is challenging for surgeons because of difficulties in proper shape restoration and maintenance of the proper long-term effect. ZrO2 implant application can be a solution with many advantages (e.g., osseointegration, stability, and radio-opaqueness) and lacks the disadvantages of other biomaterials (e.g., metalosis, radiotransparency, and no osseointegration) or autologous bone (e.g., morbidity, resorption, and low accuracy). We aimed to evaluate the possibility of using ZrO2 implants as a new application of this material for craniofacial bone defect reconstruction. First, osteoblast (skeleton-related cell) cytotoxicity and genotoxicity were determined in vitro by comparing ZrO2 implants and alumina particle air-abraded ZrO2 implants to the following: 1. a titanium alloy (standard material) 2. ultrahigh-molecular-weight polyethylene (a modern material used in orbital surgery) 3. a negative control (minimally cytotoxic or genotoxic agent action) 4. a positive control (maximally cytotoxic or genotoxic agent action). Next, 14 custom in vivo clinical ZrO2 implants were manufactured for post-traumatologic periorbital region reconstruction. The soft tissue position improvement in photogrammetry was recorded, and clinical follow-up was conducted at least 6 years postoperatively. All the investigated materials revealed no cytotoxicity. Alumina particle air-abraded ZrO2 implants showed genotoxicity compared to those without subjection to air abrasion ZrO2, which were not genotoxic. The 6-month and 6- to 8-year clinical results were aesthetic and stable. Skeleton reconstructions using osseointegrated, radio-opaque, personalized implants comprising ZrO2 material are the next option for craniofacial surgery. |
| Databáze: | OpenAIRE |
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