Effect of transforming growth factor-β1 on interleukin-6 secretion in human myoblasts
| Autor: | Paola Mazzarelli, Carlo Provenzano, Emanuela Bartoccioni, Guido Mistretta, Flavia Scuderi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
TGF alpha
medicine.medical_specialty Time Factors medicine.medical_treatment Immunology Transforming Growth Factor beta Internal medicine medicine Humans Immunology and Allergy Growth factor receptor inhibitor Interleukin 6 biology Interleukin-6 Chemistry Muscles Interleukin Drug Synergism Cell biology Endocrinology Cytokine Neurology Transforming growth factor beta 3 biology.protein Neurology (clinical) GDF15 Interleukin-1 Transforming growth factor |
| Zdroj: | Journal of Neuroimmunology. 87:185-188 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(98)00110-6 |
| Popis: | Transforming growth factor- β (TGF- β ) is involved in several autoimmune neurological diseases. It is still unclear whether its local action can be pro-inflammatory or anti-inflammatory in the muscle tissue, because of the few reports on this subject. We have previously shown that human myoblasts secrete interleukin-6 (IL-6) when stimulated with inflammatory cytokine such as interleukin-1 β (IL-1 β ) or tumor necrosis factor α . In the present report, we show that TGF- β 1 can induce IL-6 production; moreover, costimulation or short term pre-incubation with TGF- β 1 increases IL-1 β effect, while a longer incubation inhibits its action. |
| Databáze: | OpenAIRE |
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