Nocturnal ultrafiltration profiles in patients on APD: Impact on fluid and solute transport
| Autor: | Bengt Lindholm, N.D. Vega, F. Henriquez, L. Palop, Esther Oliva, J.C. Divino Filho, R. Gallego |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Ultrafiltration Urology Renal function Nocturnal Peritoneal dialysis Statistical significance medicine Humans In patient Longitudinal Studies Prospective Studies Intensive care medicine Aged Aged 80 and over Peritoneal permeability Chemistry Biological Transport Middle Aged Circadian Rhythm Ascendant Treatment Outcome Nephrology Creatinine Chronic Disease Multivariate Analysis Female Kidney Diseases Peritoneal Dialysis |
| Zdroj: | Kidney International. 73:S94-S101 |
| ISSN: | 0085-2538 |
| Popis: | In order to prevent morbidity and mortality in peritoneal dialysis (PD), sodium and water balance as well as a minimal level of small-solute clearances are needed. The impact of three nocturnal peritoneal ultrafiltration (UF) profiles on UF and small solute clearance in patients on automated PD (APD) was studied: constant glucose concentration of 1.36% (flat) or modifying the glucose concentration of the heater bag (descendant: 3.86-1.36%; ascendant: 1.36-3.86%). Sixty-two patients were enrolled in the study and received each profile within a four-month period, thus serving as their own controls. UF was lower with the flat profile (367+/-420ml; P0.01), but no difference was seen between the two higher glucose concentration profiles. Peritoneal Kt/V (pKt/V) and peritoneal creatinine clearance (CrpC) showed statistically higher values from the descendant vs ascendant vs flat profiles (pKt/V: 1.54+/-0.30 vs 1.45+/-0.30 vs 1.38+/-0.27, and CrpC: 36.9+/-7.9 vs 33.5+/-7.48 vs 29.92+/-7.5 mlmin(-1)). Multivariate analysis showed statistical significance for the following: in the intrasubject comparisons, the profile for pKt/V (F=9.109, P0.001) and CrpC (F=11.697, P0.001), and in the intersubjects comparisons, the effects of both gender (F=14.334, P0.01) for pKt/V and peritoneal permeability for both parameters (pKt/V: F=4.37, P0.05; CrpC: F=11.697, P0.001). In conclusion, the application of ascendant and descendant UF profiles in automated PD is feasible and results in better UF and small solute clearances, thus preventing inadequate dialysis and volume overload.. |
| Databáze: | OpenAIRE |
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