Genetics of emotional reactivity in bipolar disorders
| Autor: | C. Henry, Frank Bellivier, Mohamed Lajnef, Marie-Hélène Dizier, Flavie Mathieu, C. Cabon, Mark Lathrop, Bruno Etain, Marion Leboyer |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Bipolar Disorder Genotype Epistasis and functional genomics Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Covariate Genetic variation Genetic predisposition medicine Humans Genetic Predisposition to Disease Bipolar disorder Genetic Association Studies Genetics Genetic Variation Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Phenotype Multiple comparisons problem Female |
| Zdroj: | Journal of affective disorders. 188 |
| ISSN: | 1573-2517 |
| Popis: | Background Emotional reactivity has been proposed as a relevant intermediate phenotype of bipolar disorder (BD). Our goal was to identify genetic factors underlying emotional reactivity in a sample of bipolar patients. Methods Affect intensity (a proxy measure of emotional reactivity) was measured in a sample of 281 euthymic patients meeting DSM-IV criteria for BD. We use a validated dimensional tool, the 40-item self-report Affect Intensity Measure scale developed by Larsen and Diener. Patients with BD were genotyped for 475. 740 SNPs (using Illumina HumanHap550 Beadchips or HumanHap610 Quad chip). Association was investigated with a general mixed regression model of the continuous trait against genotypes, including gender as covariate. Results Four regions (1p31.3, 3q13.11, 11p15.1 and 11q14.4) with a p -value lower or equal to 5×10 −6 were identified. In these regions, the joint effect of the four variants accounted for 24.5% of the variance of AIM score. Epistasis analysis did not detect interaction between these variants. In the 11p15.1 region, the rs10766743 located in the intron of the NELL1 gene remained significant after correction for multiple testing ( p =2×10 −7 ). Conclusions These findings illustrate that focusing on quantitative intermediate phenotypes can facilitate the identification of genetic susceptibility variants in BD. |
| Databáze: | OpenAIRE |
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