Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke

Autor: Smita Savant-Bhonsale, Michael Chopp, Mei Lu, Jieli Chen, Cynthia Roberts, Alex Zacharek, Xu Cui
Rok vydání: 2009
Předmět:
Male
Simvastatin
Chemokine
Angiogenesis
Pharmacology
CXCR4
Neovascularization
Cell Movement
Bone Marrow Transplantation
Neurologic Examination
biology
Infarction
Middle Cerebral Artery
hemic and immune systems
Stroke
medicine.anatomical_structure
Neurology
medicine.symptom
medicine.drug
Receptors
CXCR4
Stromal cell
Neovascularization
Physiologic
Bone Marrow Cells
Arteriogenesis
Article
lcsh:RC321-571
stomatognathic system
medicine
Animals
cardiovascular diseases
Rats
Wistar
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Bone marrow stromal cell
Analysis of Variance
business.industry
Recovery of Function
Chemokine CXCL12
Rats
Disease Models
Animal
Bromodeoxyuridine
Gene Expression Regulation
Immunology
biology.protein
Blood Vessels
Bone marrow
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Stromal Cells
business
Zdroj: Neurobiology of Disease, Vol 36, Iss 1, Pp 35-41 (2009)
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2009.06.012
Popis: We investigated the additive therapeutic effect of the combination treatment of stroke with sub-therapeutic doses of Simvastatin, a HMG-CoA reductase inhibitor, and bone marrow stromal cells (BMSCs). Rats were administered Simvastatin (0.5 mg/kg), BMSCs (1x10(6)) or combination of Simvastatin and BMSCs starting at 24 h after stroke. Combination treatment significantly improved neurological outcome, enhanced angiogenesis and arteriogenesis, and increased the number of engrafted-BMSCs in the ischemic brain. The number of engrafted-BMSCs and arteriogenesis was significantly correlated with functional outcome. Simvastatin significantly increased stromal cell-derived factor-1 (SDF1) expression in the ischemic brain and chemokine (CXC motif) receptor-4 (CXCR4) in BMSCs, and increased BMSC migration to RBMECs and astrocytes. Combination treatment of stroke upregulates the SDF1/CXCR4 axis and enhances BMSC migration into the ischemic brain, amplifies arteriogenesis and angiogenesis, and improves functional outcome after stroke.
Databáze: OpenAIRE
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