Tissue-based research in kidney cancer: current challenges and future directions
| Autor: | Maria Merino, John Gillespie, W. Marston Linehan, Gennady Bratslavsky, Michael R. Pins, Michael B. Atkins, Andrew M. Hruszkewycz, Towia A. Libermann, George Thomas, John R. Haaga, F. M. Waldman, Joseph E. Tomaszewski, Sabina Signoretti, Carolyn C. Compton, Victor E. Reuter |
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| Rok vydání: | 2008 |
| Předmět: |
Quality Control
Cancer Research medicine.medical_specialty Pathology medicine.medical_treatment Drug Evaluation Preclinical Translational research Tissue Banks Models Biological Article Targeted therapy medicine Biomarkers Tumor Humans Medical physics Tissue Collection Carcinoma Renal Cell Paraffin Embedding business.industry Cancer Genomics medicine.disease Kidney Neoplasms Oncology Specimen collection Surgery Computer-Assisted Research Design Tissue bank Tissue and Organ Harvesting Personalized medicine business Kidney cancer Algorithms |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 14(12) |
| ISSN: | 1078-0432 |
| Popis: | The past several years have seen unprecedented advances in the application of various therapeutic strategies for the treatment of patients with renal cancer. The availability of active immunotherapy, antiangiogenic therapy, and targeted therapy for this disease has brought front and center issues related to choosing the appropriate treatment for particular patient populations. It is increasingly evident that the most promising treatment selection strategies will incorporate identifying specific features of the tumor itself. To facilitate this move toward personalized medicine, it is critically important to establish some standard principles for renal cancer tissue collection, preparation, and analysis for translational research studies. In this article, we identify and discuss some critical issues related to tissue-based kidney cancer research. We focus on five major areas as follows: (a) surgical and image-guided techniques for tissue collection; (b) quality control of specimen collection, processing, storage, and review; (c) issues related to analysis of paraffin embedded tissues; (d) genomic studies; and (e) assessment of reproducibility of assays across institutions. In addition, some practical implementation strategies are proposed. Although many of the topics discussed are specific for renal cancer, several are also relevant to tissue based biomarker investigations in a broad array of malignancies. |
| Databáze: | OpenAIRE |
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