Developing ‘integrative’ zebrafish models of behavioral and metabolic disorders
| Autor: | Adam Michael Stewart, Alina Mikhaylova, Ester Yang, R. G. Arnold, Allan V. Kalueff, Michael Nguyen, Nikhil Neelkantan, Manoj K. Poudel |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
animal structures ved/biology.organism_classification_rank.species Danio Behavioral Neuroscience Metabolic Diseases Internal medicine medicine Animals Humans Obesity Model organism Zebrafish Organism biology ved/biology Mental Disorders fungi biology.organism_classification medicine.disease Phenotype Comorbidity Disease Models Animal Endocrinology embryonic structures Anxiety medicine.symptom Neuroscience High homology Stress Psychological |
| Zdroj: | Behavioural Brain Research. 256:172-187 |
| ISSN: | 0166-4328 |
| Popis: | Recently, the pathophysiological overlap between metabolic and mental disorders has received increased recognition. Zebrafish (Danio rerio) are rapidly becoming a popular model organism for translational biomedical research due to their genetic tractability, low cost, quick reproductive cycle, and ease of behavioral, pharmacological or genetic manipulation. High homology to mammalian physiology and the availability of well-developed assays also make the zebrafish an attractive organism for studying human disorders. Zebrafish neurobehavioral and endocrine phenotypes show promise for the use of zebrafish in studies of stress, obesity and related behavioral and metabolic disorders. Here, we discuss the parallels between zebrafish and other model species in stress and obesity physiology, as well as outline the available zebrafish models of weight gain, metabolic deficits, feeding, stress, anxiety and related behavioral disorders. Overall, zebrafish demonstrate a strong potential for modeling human behavioral and metabolic disorders, and their comorbidity. |
| Databáze: | OpenAIRE |
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